liver biochemistry Flashcards
1
Q
when do aminotransferases leak into the blood
A
with liver cell damage
2
Q
where is AST also present
A
- heart
- muscle
- kidney
- brain
3
Q
what diseases is high AST seen
A
- hepatic necrosis
- MI
- muscle injury
- cardiac failure
4
Q
what is ALT
A
cytosol enzyme
5
Q
when is an ALT rise
A
only liver disease
6
Q
what is the ALT:AST ratio in hepatitis
A
ALT > AST
7
Q
what is the ALT:AST ratio in alcoholic liver disease
A
AST > ALT
8
Q
what does AST:ALT ratio of more than 1 indicate in hepatitis
A
cirrhosis
9
Q
when is ALP raised
A
in intrahepatic and extrahepatic disease
10
Q
what is gamma-GT useful for
A
guide of alcohol intake if ALP if normal
11
Q
when is globulin fraction often raised
A
in autoimmune hepatitis
12
Q
what are viruses a major cause of
A
liver disease
13
Q
when is thrombocytopenia common
A
in cirrhosis
14
Q
what can alpha1-antitrypsin deficiency produce
A
cirrhosis
15
Q
what is alpha-fetoprotein produced by
A
fetal liver
