crohns Flashcards
1
Q
what is main genetic factor
A
NOD2 gene
2
Q
where is NOD2 located
A
gene 16
3
Q
factors associated with CD
A
- smoking increases risk
- NSAIDS
- poor hygiene
- appendectomy increases risk
4
Q
what pathogen is increased
A
e.coli
5
Q
where can it affect
A
anywhere in GI tract
- tendency to be terminal ileum and ascending colon
6
Q
does it have skip lesions
A
yes
7
Q
what is it called when affects whole colon
A
total colitis
8
Q
what is it associated with the development of
A
perianal fistulae
fissures
9
Q
what is the bowel like
A
thickened and narrowed
10
Q
what do deep ulcers and fissure cause
A
cobblestoning
11
Q
what is an early feature
A
apthoid ulceration
seen in colonoscopy
12
Q
where is the inflammation
A
transmural
= through all layers
13
Q
what is there an increase of
A
chronic inflammatory cells and lymphoid hyperplasia
14
Q
is there granulomatous present
A
yes
non-caveating
15
Q
is there goblet cells present
A
yes
