Post Exposure Prophylaxis

Question 1

PEP for Hep A

Answer 1

Human Normal Immunoglobulin (HNIG)
OR Hepatitis A vaccine

Question 2

PEP for Hep B

Answer 2

• if responded to Hep B vaccine then booster dose
• Non-responder= hepatitis B immune globulin (HBIG) and booster vaccine

*if currently during vaccine course, can accelerate this

Question 3

PEP for Hep C

Answer 3

monthly PCR
- if seroconversion then interferon +/- ribavirin

Question 4

PEP for HIV

Answer 4

oral antiretrovirals
- Tenofovir, emtricitabine, lopinavir and ritonavir ASAP

(may be started up to 72 hours following exposure)

• Taken for 4 weeks
• serological testing at 12 weeks following completion of PEP

Question 5

Risk of transmission of Hep B, Hep C and HIV from needlestick injury

Answer 5

Hepatitis B 20-30%
Hepatitis C 0.5-2%
HIV 0.3%