Antifungals

Question 1

Which antifungal Inhibits 14α-demethylase which produces ergosterol

Answer 1

• Azoles
  e.g. Fluconazole, Clotrimazole

Question 2

Which antifungal binds with ergosterol forming a transmembrane channel that leads to monovalent ion (K+, Na+, H+ and Cl) leakage

Answer 2

Nystatin (topical)
Amphotericin B

Question 3

Which oral antifungal Inhibits squalene epoxidase

Answer 3

Terbinafine

Question 4

Which antifungal Interacts with microtubules to disrupt mitotic spindle

Answer 4

Griseofulvin

Question 5

Which antifungal is converted by cytosine deaminase to 5-fluorouracil, which inhibits thymidylate synthase and disrupts fungal protein synthesis

Answer 5

Flucytosine

Question 6

Which IV antifungal inhibits synthesis of beta-glucan, a major fungal cell wall component

Answer 6

Caspofungin

Question 7

Which group of antifungals cause p450 enzyme inhibition and liver toxicity?

Answer 7

-azoles
e.g. Fluconazole/ Clotrimazole

Question 8

Which antifungal causes side effects such as Nephrotoxicity, flu-like symptoms, hypokalaemia, hypomagnaseamia

Answer 8

Amphotericin B

Question 9

Which antifungal induces the p450 system and is teratogenic

Answer 9

Griseofulvin

Question 10

Side effect of flucytosine

Answer 10

Vomiting

Question 11

Side effect of caspofungin

Answer 11

Flushing