Polycystic Kidney Disease Flashcards
1
Q
What is polycystic kidney disease?
A
Genetic condition where kidneys develop multiple fluid filled cysts
2
Q
What may be felt on examination?
A
Palpable enlarged kidneys
3
Q
Diagnosis of PKD?
A
USS
Genetic testing
4
Q
Genes for AD PKD?
A
PKD-1: Chromosome 16
PKD-2: Chromosome 4
5
Q
Presnetation of PKD extra-renal?
A
- Cerebral aneurysms
- Hepatic, splenic, pancreatic, ovarian and prostatic cysts
- Cardiac valve disease (mitral regurg)
- Colonic diverticula
- Aortic root dilation
6
Q
Complications of PKD AD?
A
Chronic loin pain HT CVD Gross haematuria can occur with cyst rapture Renal stones more common ESRF at 50 years mean
7
Q
Presnetation of AR PKD?
A
Often presents in pregnancy with oligohydramnios as foetus does not produce enough urine
8
Q
What does oligohydramnios lead to?
A
Underdevelopment of lungs
9
Q
Management of PKD?
A
Tolvaptan: slows development of cysts and progression of renal failure in AD PKD
10
Q
Supportive care in PKD?
A
Anti-hypertensives
Analgesia
ABs for infection
Dialysis/transplant
