Pharmacology Unit 12 and 13 Endocrine Drugs Flashcards
With Adrenocorticosteroids, what are the Indications of using Glucocorticoids?
These are primarily involved in the control of glucose metabolism and the bodies ability to deal with stress. Glucocortoids are also able to decresae inflammation and suppress the immune system
With Adrenocorticosterioids, what are the Indications of using Mineral Corticoids?
These are primarily involved in maintaining fluid and electrolyte balance in the body. This hormone works on the kidneys to increase soidum and water reabsorption and potassium excretion
For Mineral Corticoids, there are agonist and antagonist drugs
Adrenocorticosteroids
What are the Adverse Effects of Glucocoticoids?
- Adrenal Suppression
- Drug-Induced Cushing Syndrome:
-Hypertension
-Osteoporosis
-Glucose Intolerance
-Roundness, puffiness in the face - Tissue Breakdown: Muscle, Ligament, Bone, Skin
- Increase in blood glucose (hyperglycemia)
Adrenocorticosteroids
What are the Adverse Effects of Mineral Corticoids Agonist?
- Hypertension
- Peripheral Edema
- Hypokalemia (M. weakness, cramps, spasms, fatigue, etc.)
- Weight Gain
Adrenocorticosteroids
What are the Adverse Effects of Mineral Corticoids Antagonist?
- Hyperkalemia (excess potassium)
- Changes to endogenous sex hormones
-
CNS effects:
-Drowsiness
-Lethargy
-Confusion
-Headache
What are the Considerations for PT, when Pt are taking Adrenocorticosteroids?
- PT must be careful to avoid overstressing tisses that are weakened by the prolonged systemic glucocorticoids, so gradual progression is important. Also those with osteoporosis, because it can accelerate the bone loss.
- Assessing vitals is important due to some adverse effects are hypertension.
- PTs should be mindful of Sx of hypokalemia, this is life-threatening if not managed.
- We must assess blood glucose prior to exercise
- CNS effects may place the patient as a greater risk for falls, so we must use gait belt
What are the Indications of Thyroid Drugs?
These are used to regulate thyroid hormone levels
Thyroid Drugs
What is the Role of Antithyroid Agents?
These inhibit thyroid hormone synthesis and/or block conversion of T4 to T3 in peripheral tissue
Thyroid Drugs
What is the Role of Iodide?
These limit the uptake of iodide into thyoid follicle cell, inhibit the formation of T4 and T3, and decrease the secretion of the completed hormones from the thyroid cell
Thyroid Drugs
What is the Role of Radioactive Iodine?
These selectively destroys the thyroid follicle cells
Follicle cells are cells in the thyroid gland
Thyroid Drugs
What is the Role of Beta-Adrenergic Blockers?
These help suppress Sx such as tachycardia, palpitations, fever, and restlessness due to thyroid strom
Thyroid Drugs
What is the Role of Thyroid Hormones?
These are used to restore thyroid levels to manage hypothyroidism
Thyroid Drugs
What are the Adverse Effects of Antithyroid Drugs?
- Skin rash
- Overdose: lethargy, feeling cold
Thyroid Drugs
What are the Adverse Effects of Iodide?
Hypertensive Reaction
Thyroid Drugs
What are the Adverse Effects of Radioactive Iodine?
- Eye Sx (redness, inflammation, redness, bulging)
- Beta Blockers (Hypotension)
Thyroid Drugs
What are the Adverse Effects of Throid Hormones?
- Overdose
-Nervousness, weight loss, Tachycardia, Muscle Wasting, goiter
Parathyroid Drugs
What are the Indications for Parathyroid Drugs?
These are for the regulation of bone mineral hemeostasis
Parathyroid Drugs
What is the Role of Bisphosphonates?
These block excessive bone resorption and formation
Parathyroid Drugs
What is the role of Vitamine D?
These enhace bone formation by increasing the supply of the two primary minerals needed for bone formation (calcium and phosphate)