CNS Exam 1 Flashcards
What are the 5 steps of Embryological development?
- Neurulation: Formation of the neural crest and neural tube
- Cell Proliferation: within neural tube
- Migration and Aggregation: of cells within definitive locations
- Formation of axonal and dendritic processes
- Synatopgenesis: connections between nerve cell to nerve cells or muscle
What are the Embryologic names for Forebrain, Midbrain, and Forebrain?
Prosencephalon (Forebrain)
Mesencephalon (Midbrain)
Rhombencephalon (Hindbrain)
What are the 2 subdivisions of Prosencephalon?
- Telencephalon
- Diencephalon
The Telencephalon is a subdivision of the Prosencephalon. What are the parts (Derivates) of the Telencephalon?
- Cerebral Hemispheres
- Cerebral Cortex
- Subcortical White Matter
- Basal Ganglion
- Basal Forebrain Nuclei
The Diencephalon is a subdivision of the Prosencephalon. What are the parts (Derivates) of the Diencephalon?
- Thalamus
- Hypothalamus
- Epithalamus
What are the Parts of the Mesencephalon (midbrain)?
In the future this connects the forebrain to the hindbrain
- Cerebral Peduncles
- Midbrain Tectum
- Midbrain Tegmentum
The Metencephalon is a subdivision of the Rhombencephalon. What are the parts (Derivates) of the Metencephalon?
- Pons
- Cerebellum
The Myelencephalon is a subdivision of the Rhombencephalon. What are the parts (Derivates) of the Myelencephalon?
- Medulla
What are the 2 Primary Flexures of the Brain?
What is the third flexure?
The Two Primary Flexures are:
- Cephalic Flexure, which marks the division between the brain and the brainstem
- Cervical Flexure, which is the junction of the Spinal Cord to the Brain
The 3rd Flexure is:
- The Pontine Flexure, which is found on the dorsum and is the future site of the cerebellum
The fluid-filled cavities within the neural tube develop in to what? What do they contain?
Develops into the Brain Ventricles, which contain Cerebrospinal Fluid
In the second stage of Embryologic development (Cell Proliferation) following the closer of the neural tube, postmitotic cells are pushed externally and are divided into 3 layers. What are the 3 layers and what do they later become?
- Germinal (Ependymal) Layer: This is the inner layer, this then becomes the lining of the central canal and ventricles- these cells develop cilia that help move Cerebral Spinal Fluid (CSF)
- Mantle Layer: This becomes the GREY MATTER of the spinal cord due to the cell bodies there-The Sulcus Limitans appears, above is the Alar Plate (sensory) and below is the Basilar Plate (motor)
- Marginal Layer: The outermost layer that contains most of the processes from the cell bodies of the mantle- It becomes the WHITE MATTER
In the third stage of Embryologic Development (Migration), there are 2 types of migration. What are they?
- Radial Migration
- Tangential Migration
What are some defects in the 3rd stage of embryological development?
- Dyslexia
- Lissencephaly (“Smooth brain” results in motor and mental retardation)
- Microencephaly (Small brain results in mental retardation)
- Macrogyria (Some folding but not normal have less gyri)
In stage 4 of Embryological development (Cell Differentiation), what happens?
- There is the formation of axonal and dendritic processes
- Development of cranial nerves
Which parts of our brain controls our basic functions necessary for survival: respiration, BP, and HR?
Brainstem: Midbrain, Pons, Medulla
(Also the most evolutionary ancient parts of the brain)
How is Cerebral Spinal Fluid (CSF) formed?
Its formed by vascular tufts lying within the ventricles called Choroid Plexus
How does the CSF circulate? Where does it leave?
- CSF circulates from the lateral ventricles to the third ventricle, and then leaves the ventricular system via foramina in the fourth ventricle to percolate around the outside surface of the brain and spinal cord.
In the brain, what are the Meninges?
MNEMONIC - PAD
From inside - out:
- Pia Mater
- Arachnoid Mater
- Dura Mater
In the brain there is a Dura Mater structure called the Falx Cerebri, where is it and what does it do?
- This structure dips in-between the cerebral hemispheres between the longitudinal fissure
- This is a very tough and very thick layer for the purpose of keeping the our brain from moving around in the skull
What are the differences in terms of Orientation of the Brain (Midbrain) and Spinal Cord?
Above the Midbrain:
- Anterior = Rostral
- Posterior = Caudal
- Superior = Dorsal
- Inferior = Ventral
Below the Midbrain (like Spinal cord)
- Anterior = Ventral
- Posterior = Dorsal
- Superior = Rostral
- Inferior = Caudal
In terms of Orientation, where is the Thalamus compared to the Frontal Lobe?
The Thalamus is Caudal to the Frontal Lobe
In terms of Orientation, where is the Cerebellum compared to the Pons?
The Cerebellum is Dorsal to the Pons
In terms of Orientation, where is the Anterior horn of the SC compared to the Posterior horn of SC?
The Anterior horn of SC is Ventral to Posterior horn of SC
In neurons, what do Dendrites and Axons do? What are Glia Cells?
Dendrites are the processes that receive information into the cell
Axons are acting to carry information away
- Everything outside of the neuron or nerve-cell is considered glial cells (Support cells)