Pharmacology + Pain Flashcards
Theoretical volume in body in which drug may be found after absorption
Amount of drug / plasma concentration immediately after dosing
Volume of distribution
Fraction of drug cleared from body in any given unit of time
Clearance
Amount of administers drug that actually reached blood
Bioavailability
Percentage of drugs cleared from body after 5 half-lives
~97%
(3.125% will remain)
Amount of half-lives to reach steady state
5
Progression of drug from site of administration to target site
Absorption
Effect of dairy products on tetracycline, doxycycline, ciproflxaxin
Chelation
Effects of cephalosporins and fluoroquinolones on Ca, Mg, aluminum compounds
Decrease bioavailability
Effects of antacid on iron supplements
Antacid will bind iron and prevent its absorption
Where drug disperses after successfully absorbed into systemic circulation
Distribution
Effect of sulfa drugs on phenytoin
Unbind phenytoin from plasma proteins. Increasing its potential toxicity and elimination
Effect of cranberry juice on warfarin
Increases its effects.
Potentially causes bleeding
CYP Inhibitors
Erythromycin
Ciprofloxaxin
Cimetidine
Omeprazole
Reduce metabolism
Increase bioavailability and toxicity
CYP inducers
Rifampin
Phenobarbital
Carbamazepine
Phenytoin
Increase metabolism
Eliminate quicker
Effect of quinidine and amiodarone on digoxin
Inhibit renal metabolism
Increasing levels
