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Year 2 neuro exam 1 > Pharm NT III > Flashcards

Pharm NT III Flashcards

1
Q

synthesis serotonin

A

presynaptic terminal from tryptophan by tryptophan hydroxylase

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2
Q

storage serotonin

A

vesicular transporter

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3
Q

inactivation serotonin

A

serotonin uptake transporter SERT

pumps 5-HT back into nerve terminal

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4
Q

R activated by serotonin

A

ionotropic (excitatory)

metabotropic (5-Ht 1,2,4,5,6,7)

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5
Q

activation 5-HT1

A

inhibitory increase K dec cAMP

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6
Q

activation 5-HT2a

A

excitatory

dec K increase IP3 and dAG

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7
Q

activation 5-HT 4

A

excitatory

dec K

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8
Q

where are serotonergic neurons located

A

raphe nuclei or medulla, pons and upper brainstem

peripherally in GI tract

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9
Q

SSRIs

A

selective serotonin reuptake inhibitors used in depression

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10
Q

what is fluoxetine

A

prozac

SSRI

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11
Q

what drugs maybe interact with 5-HT R

A

ecstasy LSD and other hallucinogens

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12
Q

ondansetron

A

5-HT3 R antagonist (antiemetic)

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13
Q

partial agonists 5-HT2A

A

atypical antipsychotics

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14
Q

R for histmaine

A

metabotropic H1-4

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15
Q

activation H1 R

A

excitatory dec K increase IP3 and DAG

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16
Q

activation H2 R

A

excitatory dec K, increase cAMP

17
Q

synthesis of peptide NT

A

neuropeptides made in cell body

18
Q

storage neuropeptides

A

large dense core vesciles

19
Q

Substance P

A

transmitter for sensory afferent neurons mediating pain

20
Q

endogenous opioid peptides are involved in what

A

pain pathways

21
Q

activation of u type opioid R cause what

A

inhibitory

dec Ca dec cAMP

22
Q

activation of delta enkephalin and kappa dynorphin R cause what

A

inhibitory

increase K dec cAMP

23
Q

synthesis of endocannabinoids

A

locally and rapidly in response to depolarizaiton and Ca influx

24
Q

storage endacannabinoids

A

not in vesicles

25
Q

release endocannabinoids

A

released from post synaptic cell and travel backwards across cleft
modulate release of glutamate and GABA

26
Q

what R is in brain for endocannabinoids

A

CB1

27
Q

what R is on immune cells for endocannabinoids

A

CB2

28
Q

activation CB1

A

inhibitory
dec Ca dec cAMP
dec Nt release

29
Q

pathophys endocannabinoids

A

memory cognition and pain perception

Year 2 neuro exam 1 (23 decks)

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