Pharm NT III Flashcards
synthesis serotonin
presynaptic terminal from tryptophan by tryptophan hydroxylase
storage serotonin
vesicular transporter
inactivation serotonin
serotonin uptake transporter SERT
pumps 5-HT back into nerve terminal
R activated by serotonin
ionotropic (excitatory)
metabotropic (5-Ht 1,2,4,5,6,7)
activation 5-HT1
inhibitory increase K dec cAMP
activation 5-HT2a
excitatory
dec K increase IP3 and dAG
activation 5-HT 4
excitatory
dec K
where are serotonergic neurons located
raphe nuclei or medulla, pons and upper brainstem
peripherally in GI tract
SSRIs
selective serotonin reuptake inhibitors used in depression
what is fluoxetine
prozac
SSRI
what drugs maybe interact with 5-HT R
ecstasy LSD and other hallucinogens
ondansetron
5-HT3 R antagonist (antiemetic)
partial agonists 5-HT2A
atypical antipsychotics
R for histmaine
metabotropic H1-4
activation H1 R
excitatory dec K increase IP3 and DAG
activation H2 R
excitatory dec K, increase cAMP
synthesis of peptide NT
neuropeptides made in cell body
storage neuropeptides
large dense core vesciles
Substance P
transmitter for sensory afferent neurons mediating pain
endogenous opioid peptides are involved in what
pain pathways
activation of u type opioid R cause what
inhibitory
dec Ca dec cAMP
activation of delta enkephalin and kappa dynorphin R cause what
inhibitory
increase K dec cAMP
synthesis of endocannabinoids
locally and rapidly in response to depolarizaiton and Ca influx
storage endacannabinoids
not in vesicles
release endocannabinoids
released from post synaptic cell and travel backwards across cleft
modulate release of glutamate and GABA
what R is in brain for endocannabinoids
CB1
what R is on immune cells for endocannabinoids
CB2
activation CB1
inhibitory
dec Ca dec cAMP
dec Nt release
pathophys endocannabinoids
memory cognition and pain perception
