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Year 2 neuro exam 1 > Pharm NT II > Flashcards

Pharm NT II Flashcards

1
Q

What does glycine do

A

ligant gated Cl Ch

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2
Q

what toxin inhibits glycine release

A

tatanus

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3
Q

what is antagonist for glycine

A

strychnine

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4
Q

glycine also acts as agonist where

A

NMDA R

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5
Q

synthesis Ach

A

presynaptic terminal from choline and acetyl CoA

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6
Q

what helps store Ach

A

vesicle associated transporter

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7
Q

inactivation Ach

A

ACHE

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8
Q

R activated by Ach

A

ionotropic (nicotinic)

metabotropic (muscarinic)

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9
Q

agonist for ionotropic Ach

A

nicotine

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10
Q

antagonist for ionotropic Ach

A

curare like drugs (nondepolarizing neuromuscular blockers)

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11
Q

M1 Ach R

A

excitatory

dec K increase IP3 and DAG

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12
Q

M2 type Ach R

A

increase K
dec cAMP
inhibitory

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13
Q

agonist to muscarininc Ach R

A

muscarine and pilocarpine

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14
Q

antagonist to muscarininc Ach R

A

atropine and glycopyrrolate

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15
Q

roles of Ach in CNA

A

midbrain reticular formation- wakefulness
basal ganglia-motor control
basal forebrain- connections to hippocampus and Cx

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16
Q

Ach in Alzheimers

A

reduced production choline acetyl transferase dec Ach synthesis and impaired cortical cholinergic function

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17
Q

used to treat alzhemiers to counter dec in Ach production

A

ACHE inhibitors

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18
Q

What NMJ diseases involve Ach dysregulation

A

myasthenia gravis
Eaton Lambert Syndrome
botulism

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19
Q

what occurs when CNA Ach R blocked

A

drowsiness, sedation and memory loss

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20
Q

dopamine synthesis

A

presynatpic terminal form tyrosine

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21
Q

storage dopamine

A

loaded by vesciular monoamine transporter

22
Q

inactivaiton dopamine

A

reuptake into presynaptic cells mediated by dopamine transporter DAT(majoirty) and plasma membrane monoamine transpoters

23
Q

dopamine R

A

D1-5

24
Q

D1 R activation causes what

A

increase cAMP

stimulatory

25
Q

D2 R activation

A

inhibitory
postsynaptic increase K decrease cAMP
presynaptic dec Ca

26
Q

where are the cell bodies of dopaminergic neurons

A

midbrain with substantia nigra pars compacta and in hypothalamus

27
Q

what do midbrain dopaminergic neurons influence

A

motor control, emotion, motivation and cognitive processes like memory

28
Q

Parkinsons

A

DA neurons in striatum degenerate

29
Q

shizophrenia/psychosis

A

increased dopaminergic activity

30
Q

what is used to Tx shizophrenia

A

D2 R antagonists

31
Q

how does cocaine effect dopamine

A

DA uptake blockate

32
Q

amphetamines change dopamine how

A

increase dopamine release

33
Q

reward pathway

A

ventral tegmental dopamine pathways that mediate subjective effects of drugs of abuse

34
Q

norepi synthesis

A

NE granules from dopamine by dopamine beta hyroxylase

35
Q

storage NE

A

in grnaules where made

36
Q

inactivation NE

A

reuptake mediated by norepri transporter

37
Q

what R noes norepi work on

A

metabotropic
alpha 1 2
beta 1,2,3

38
Q

a1 stimulation by NE

A

excitatory

dec K, increase IP3 and DAG

39
Q

agonist for alpha 1 R

A

phenyleprhine

40
Q

antagonist for alpha 1 R

A

phentolamine, prasozin

41
Q

activation alpha 2 R

A

inhibitory
postsynaptic inc K dec cAMP
pre: dec Ca

42
Q

agonist alpha 2

A

clonidine

43
Q

antagonist to alpha2

A

yohimbine

44
Q

activation beta 1

A

exctitatory

dec K increase cAMP

45
Q

agonist beta 1

A

isoproterenol

46
Q

antagonist beta1

A

propranolol

47
Q

activation beta 2

A

excitatory

increase cAMP

48
Q

agonist beta 2

A

albtuerol

49
Q

antaonist beta 2

A

butoxamine

50
Q

where are cell bodies for noradrenergic neurons

A

locus ceruleus

51
Q

what do NE neurons modulate

A

sleep, wakefulness, attention and feeding behaviors

52
Q

NE has what role in mood disorders

A

depression

Year 2 neuro exam 1 (23 decks)

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