Pharm NT II

Question 1

What does glycine do

Answer 1

ligant gated Cl Ch

Question 2

what toxin inhibits glycine release

Answer 2

tatanus

Question 3

what is antagonist for glycine

Answer 3

strychnine

Question 4

glycine also acts as agonist where

Answer 4

NMDA R

Question 5

synthesis Ach

Answer 5

presynaptic terminal from choline and acetyl CoA

Question 6

what helps store Ach

Answer 6

vesicle associated transporter

Question 7

inactivation Ach

Answer 7

ACHE

Question 8

R activated by Ach

Answer 8

ionotropic (nicotinic)

metabotropic (muscarinic)

Question 9

agonist for ionotropic Ach

Answer 9

nicotine

Question 10

antagonist for ionotropic Ach

Answer 10

curare like drugs (nondepolarizing neuromuscular blockers)

Question 11

M1 Ach R

Answer 11

excitatory

dec K increase IP3 and DAG

Question 12

M2 type Ach R

Answer 12

increase K
dec cAMP
inhibitory

Question 13

agonist to muscarininc Ach R

Answer 13

muscarine and pilocarpine

Question 14

antagonist to muscarininc Ach R

Answer 14

atropine and glycopyrrolate

Question 15

roles of Ach in CNA

Answer 15

midbrain reticular formation- wakefulness
basal ganglia-motor control
basal forebrain- connections to hippocampus and Cx

Question 16

Ach in Alzheimers

Answer 16

reduced production choline acetyl transferase dec Ach synthesis and impaired cortical cholinergic function

Question 17

used to treat alzhemiers to counter dec in Ach production

Answer 17

ACHE inhibitors

Question 18

What NMJ diseases involve Ach dysregulation

Answer 18

myasthenia gravis
Eaton Lambert Syndrome
botulism

Question 19

what occurs when CNA Ach R blocked

Answer 19

drowsiness, sedation and memory loss

Question 20

dopamine synthesis

Answer 20

presynatpic terminal form tyrosine

Question 21

storage dopamine

Answer 21

loaded by vesciular monoamine transporter

Question 22

inactivaiton dopamine

Answer 22

reuptake into presynaptic cells mediated by dopamine transporter DAT(majoirty) and plasma membrane monoamine transpoters

Question 23

dopamine R

Answer 23

D1-5

Question 24

D1 R activation causes what

Answer 24

increase cAMP

stimulatory

Question 25

D2 R activation

Answer 25

inhibitory postsynaptic increase K decrease cAMP presynaptic dec Ca

Question 26

where are the cell bodies of dopaminergic neurons

Answer 26

midbrain with substantia nigra pars compacta and in hypothalamus

Question 27

what do midbrain dopaminergic neurons influence

Answer 27

motor control, emotion, motivation and cognitive processes like memory

Question 28

Parkinsons

Answer 28

DA neurons in striatum degenerate

Question 29

shizophrenia/psychosis

Answer 29

increased dopaminergic activity

Question 30

what is used to Tx shizophrenia

Answer 30

D2 R antagonists

Question 31

how does cocaine effect dopamine

Answer 31

DA uptake blockate

Question 32

amphetamines change dopamine how

Answer 32

increase dopamine release

Question 33

reward pathway

Answer 33

ventral tegmental dopamine pathways that mediate subjective effects of drugs of abuse

Question 34

norepi synthesis

Answer 34

NE granules from dopamine by dopamine beta hyroxylase

Question 35

storage NE

Answer 35

in grnaules where made

Question 36

inactivation NE

Answer 36

reuptake mediated by norepri transporter

Question 37

what R noes norepi work on

Answer 37

metabotropic alpha 1 2 beta 1,2,3

Question 38

a1 stimulation by NE

Answer 38

excitatory | dec K, increase IP3 and DAG

Question 39

agonist for alpha 1 R

Answer 39

phenyleprhine

Question 40

antagonist for alpha 1 R

Answer 40

phentolamine, prasozin

Question 41

activation alpha 2 R

Answer 41

inhibitory postsynaptic inc K dec cAMP pre: dec Ca

Question 42

agonist alpha 2

Answer 42

clonidine

Question 43

antagonist to alpha2

Answer 43

yohimbine

Question 44

activation beta 1

Answer 44

exctitatory | dec K increase cAMP

Question 45

agonist beta 1

Answer 45

isoproterenol

Question 46

antagonist beta1

Answer 46

propranolol

Question 47

activation beta 2

Answer 47

excitatory | increase cAMP

Question 48

agonist beta 2

Answer 48

albtuerol

Question 49

antaonist beta 2

Answer 49

butoxamine

Question 50

where are cell bodies for noradrenergic neurons

Answer 50

locus ceruleus

Question 51

what do NE neurons modulate

Answer 51

sleep, wakefulness, attention and feeding behaviors

Question 52

NE has what role in mood disorders

Answer 52

depression