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UWORLD Notecards > Pharm > Flashcards

Pharm Flashcards

1
Q

Name some drugs that should be avoided in the elderly

A 
Antihistamines (benydryl)
TCA's
Benzo
Sulfonylureas
Indimethicin
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2
Q

Drug of choice for the treatment of paroxysmal supra ventricular tachycardia

A

Adenosine

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3
Q

Action of adenosine

A

Slows conduction through the AV node by hyper polarizing the nodal pacemaker and conducting cells

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4
Q

Side effects of adenosine

A

Flushing, chest burning (bronchi spams ) and hypotension

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5
Q

Drug used for chemical cardiac stress test

A

Adenosine

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6
Q

Name two drugs that are metabolized by methylation

A

6-MC

Azathioprine

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7
Q

Name a syndrome associated with a dysfunction of glucuronyl transferase system that can lead to the toxic accumulation of some drugs because of the lack of glucuronidation

A

Gilbert syndrome

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8
Q

Bilirubin is metabolized by what method

A

Glucuronidation

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9
Q

Chest pain that occurs with activity only

A

Stable angina

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10
Q

Why avoid nitrates in HOCM

A

Because they decrease left ventricular volume which worsens left ventricular tract obstruction which worsens the situation

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11
Q

Raynuad is associated with what drugs

A

Amphetamines
Ergotamine
Chemo drugs

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12
Q

The ability for a drug to illicit and effect?

A

Efficacy

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13
Q

The dose of a drug that is needed to produce a given effect

A

Potency

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14
Q

Lower ED 50 means what?

A

A greater amount of potency

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15
Q

What does the stimulation of D1 do

A

Raises cAMP and causes vasodilation in most arterial beds and decreases BP

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16
Q

What is a D1 receptor short acting agonist used in severe HtN

A

Fenoldopam

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17
Q

A drug that causes renal vasodilation and increases naturesis. Mainly used for HTN emergency

A

Fenoldopam

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18
Q

Name a drug that is responsible for inhibiting GP 2b/3a from binding to fibrinogen stabilizing a platlet plug

A

Abciximab

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19
Q

What does Argatroban treat

A

Heparin induced thrombocytopenia

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20
Q

How does clopidgrel block platlet Adp receptors

A

By blocking P2Y12

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21
Q

Three drugs that can cause aplastic anemia

A

Carbamazepine
Chloramphenicol
Sulfonamides

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22
Q

Side effects of gentamicin

A

Vestibular and cochlear ototoxicity and nephrotoxicity

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23
Q

What happens when metronidazole is taken with alcohol

A

Disulfiram like reaction

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24
Q

What is used for heparin reversal

A

Protamine

25
Q

At high doses what does desmopressin do

A

Increases factor eight activity in hemophilia a and Von willebrand disease patients

26
Q

Drug thy treats hyperemesis gravidarum

A

Promethazine (antihistamine drug)

27
Q

Antihistamine drugs that treat vomiting

A

Diphenhydramine
Meclizine
Promethazine

28
Q

Dopamine receptor antagonist drugs that treat vomit

A

Prochlorperazine

Metoclorpramide

29
Q

Neurokin 1 receptor antagonist that treat chemo associated vomiting

A

Aprepitant

Fosaprepitant

30
Q

Five receptors associate with the area prostrema (vomiting)

A 
M1
D2
H1
Serotonin
Neurokinin 1
31
Q

A drug that is a motilin that is used for gastroparesis

A

Erythromycin

32
Q

What is the neurotransmitter that plays a role in pain and appetite and is found in the ANS

A

Neuropeptide Y

33
Q

Ganciclovir treats CMV and had a UDE of what

A

Neutropenia

34
Q

Adding TMP-SMX to ganciclovir causes what

A

Bone marrow suppression

35
Q

Didansoine is an antiretroviral drug that can cause what adverse reaction

A

Pancreatitis

36
Q

What are plasma cells susceptible to

A

Proteosome inhibitors called
Bortezomib
Boronic acid containing dipeptide
(Induce apoptosis in malignant plasma cells)

37
Q

Heparin induced thrombocytopenia leads to thrombosis not bleeding and is associated with antibodies to what

A

Factor 4 and heparin

38
Q

Decreased factor 8 is associated with hemophilia?

A

A

39
Q

Decreased factor nine is associated with hemophilia?

A

B

40
Q

People with hemophilia a can control bleeding with what

A

DDAVP (desmopressin)

41
Q

Drug of choice for beta blocker overdose

A

Glucagon

42
Q

Action of glucagon on the heart

A

It increases cAMP and increases heart rate and contractility

43
Q

Burning in urination and urgency is a side effect associated with what anti cancer drug

A

Cyclophosphamide

44
Q

Ant cancer drug that causes progressive pulmonary fibrosis that can cause death in some patients

A

Bleomycin

45
Q

Mercaptoourine is associated with what side effect

A

Jaundice and abdominal pain

46
Q

Monoclonal antibody used for RA and Ankylosing Spondylitis (antibody against TNF alpha)

A

Infliximab

47
Q

IL 2 treats what two things

A

Renal cell carcinoma and melanoma

48
Q

Drug that inhibits BCR/ABL AND treats CmL

A

Imatinib

49
Q

What turns Uric acid into allantoin which is more soluble then Uric acid. Used in tumor lysis syndrome

A

Rasburicase

50
Q

Drug used to counter methotrexate induced block of folic acid metabolism

A

Folinic acid (leucovorin)

51
Q

What activates 6MCP

A

hGPRT

52
Q

What inactivated 6MCP

A

Xanthine oxidase

53
Q

What is the use for Cladribine

A

Hair cell leukemia (resistant to the degradation of ADA)

54
Q

What is a drug that can cause prolonged QT but not likely to cause torsades de pointes

A

Amiodarone

55
Q

What to give to partners with aspirin allergy who need a cardio protective drug

A

Clopidgrel

56
Q

What drug causes an increases in LDl cholesterol and triglycerides because it increases insulin resistance in peripheral tissue

A

Thiazides

57
Q

hormones that use cAMP

A
  • TSH
  • ACTH
  • HCG
58
Q

what is P-glycoprotein

A

it is a human multi drug resistance transmembrane ATP-dependent efflux pump protein that reduces the influx of drugs into the CNS, blocking the action of chemotherapeutic agents

UWORLD Notecards (32 decks)

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