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UWORLD Notecards > Pharm > Flashcards

Pharm Flashcards

1
Q

Name some drugs that should be avoided in the elderly

A 
Antihistamines (benydryl)
TCA's
Benzo
Sulfonylureas
Indimethicin
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2
Q

Drug of choice for the treatment of paroxysmal supra ventricular tachycardia

A

Adenosine

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3
Q

Action of adenosine

A

Slows conduction through the AV node by hyper polarizing the nodal pacemaker and conducting cells

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4
Q

Side effects of adenosine

A

Flushing, chest burning (bronchi spams ) and hypotension

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5
Q

Drug used for chemical cardiac stress test

A

Adenosine

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6
Q

Name two drugs that are metabolized by methylation

A

6-MC

Azathioprine

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7
Q

Name a syndrome associated with a dysfunction of glucuronyl transferase system that can lead to the toxic accumulation of some drugs because of the lack of glucuronidation

A

Gilbert syndrome

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8
Q

Bilirubin is metabolized by what method

A

Glucuronidation

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9
Q

Chest pain that occurs with activity only

A

Stable angina

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10
Q

Why avoid nitrates in HOCM

A

Because they decrease left ventricular volume which worsens left ventricular tract obstruction which worsens the situation

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11
Q

Raynuad is associated with what drugs

A

Amphetamines
Ergotamine
Chemo drugs

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12
Q

The ability for a drug to illicit and effect?

A

Efficacy

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13
Q

The dose of a drug that is needed to produce a given effect

A

Potency

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14
Q

Lower ED 50 means what?

A

A greater amount of potency

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15
Q

What does the stimulation of D1 do

A

Raises cAMP and causes vasodilation in most arterial beds and decreases BP

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16
Q

What is a D1 receptor short acting agonist used in severe HtN

A

Fenoldopam

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17
Q

A drug that causes renal vasodilation and increases naturesis. Mainly used for HTN emergency

A

Fenoldopam

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18
Q

Name a drug that is responsible for inhibiting GP 2b/3a from binding to fibrinogen stabilizing a platlet plug

A

Abciximab

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19
Q

What does Argatroban treat

A

Heparin induced thrombocytopenia

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20
Q

How does clopidgrel block platlet Adp receptors

A

By blocking P2Y12

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21
Q

Three drugs that can cause aplastic anemia

A

Carbamazepine
Chloramphenicol
Sulfonamides

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22
Q

Side effects of gentamicin

A

Vestibular and cochlear ototoxicity and nephrotoxicity

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23
Q

What happens when metronidazole is taken with alcohol

A

Disulfiram like reaction

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24
Q

What is used for heparin reversal

25
At high doses what does desmopressin do
Increases factor eight activity in hemophilia a and Von willebrand disease patients
26
Drug thy treats hyperemesis gravidarum
Promethazine (antihistamine drug)
27
Antihistamine drugs that treat vomiting
Diphenhydramine Meclizine Promethazine
28
Dopamine receptor antagonist drugs that treat vomit
Prochlorperazine | Metoclorpramide
29
Neurokin 1 receptor antagonist that treat chemo associated vomiting
Aprepitant | Fosaprepitant
30
Five receptors associate with the area prostrema (vomiting)
``` M1 D2 H1 Serotonin Neurokinin 1 ```
31
A drug that is a motilin that is used for gastroparesis
Erythromycin
32
What is the neurotransmitter that plays a role in pain and appetite and is found in the ANS
Neuropeptide Y
33
Ganciclovir treats CMV and had a UDE of what
Neutropenia
34
Adding TMP-SMX to ganciclovir causes what
Bone marrow suppression
35
Didansoine is an antiretroviral drug that can cause what adverse reaction
Pancreatitis
36
What are plasma cells susceptible to
Proteosome inhibitors called Bortezomib Boronic acid containing dipeptide (Induce apoptosis in malignant plasma cells)
37
Heparin induced thrombocytopenia leads to thrombosis not bleeding and is associated with antibodies to what
Factor 4 and heparin
38
Decreased factor 8 is associated with hemophilia?
A
39
Decreased factor nine is associated with hemophilia?
B
40
People with hemophilia a can control bleeding with what
DDAVP (desmopressin)
41
Drug of choice for beta blocker overdose
Glucagon
42
Action of glucagon on the heart
It increases cAMP and increases heart rate and contractility
43
Burning in urination and urgency is a side effect associated with what anti cancer drug
Cyclophosphamide
44
Ant cancer drug that causes progressive pulmonary fibrosis that can cause death in some patients
Bleomycin
45
Mercaptoourine is associated with what side effect
Jaundice and abdominal pain
46
Monoclonal antibody used for RA and Ankylosing Spondylitis (antibody against TNF alpha)
Infliximab
47
IL 2 treats what two things
Renal cell carcinoma and melanoma
48
Drug that inhibits BCR/ABL AND treats CmL
Imatinib
49
What turns Uric acid into allantoin which is more soluble then Uric acid. Used in tumor lysis syndrome
Rasburicase
50
Drug used to counter methotrexate induced block of folic acid metabolism
Folinic acid (leucovorin)
51
What activates 6MCP
hGPRT
52
What inactivated 6MCP
Xanthine oxidase
53
What is the use for Cladribine
Hair cell leukemia (resistant to the degradation of ADA)
54
What is a drug that can cause prolonged QT but not likely to cause torsades de pointes
Amiodarone
55
What to give to partners with aspirin allergy who need a cardio protective drug
Clopidgrel
56
What drug causes an increases in LDl cholesterol and triglycerides because it increases insulin resistance in peripheral tissue
Thiazides
57
hormones that use cAMP
- TSH - ACTH - HCG
58
what is P-glycoprotein
it is a human multi drug resistance transmembrane ATP-dependent efflux pump protein that reduces the influx of drugs into the CNS, blocking the action of chemotherapeutic agents

UWORLD Notecards (32 decks)

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