Peptic Ulcer Drugs

Question 1

Where is acid secreted from and what is this stimulated by? What receptor?

Answer 1

Parietal Cells by on H2 receptors histamine from paracrine cells near to parietal cells.

Question 2

What stimulates acid production?

Answer 2

ACh through vagal fibres (sympa)
Gastrin from G cells in response to amino acids in the stomach
Gastic distension (local and long reflexes)

Question 3

What is Ranitidine?

Answer 3

H2 receptor antagonist

Question 4

How fast is Ranitidine at working?

Answer 4

Rapid when taken orally

Question 5

What are Omeprazole and Lonzoprazole?

Answer 5

Proton Pump Inhibitors

Question 6

How long are Omeprazole and Lanzoprazole effective for?

Answer 6

They bind irreversibly making them very long acting as body can only respond by creating new pumps.

Question 7

What are PPIs useful in the treatment of?

Answer 7

H. pylori

Question 8

Name a mucosal protectant

Answer 8

Sucrafate- sticks like a gel on ulcer site

Question 9

How to antacids work?

Answer 9

Increase luminal pH which speeds up gastric emptying

Question 10

How long are antacids effective for?

Answer 10

Very short term

Question 11

What is the downside of antacids?

Answer 11

Acid rebound when they are stopped

Question 12

What compounds are found in antacids?

Answer 12

Sodium bicarb

Magnesium hydroxide

Question 13

How do you test for H pylori?

Answer 13

Urea breath test

Question 14

How do you treat H pylori?

Answer 14

PPI and antibiotics triple therapy

Omeprazole and Clarithromycin and Azithromycin