Anaemia drugs Flashcards
What does erythropoiesis require?
Iron
Vit B12
Folic Acid
What aspect of blood is Fe needed for
Haemoglobin production
What does Fe deficient anaemia look like?
Microcytic Hypochromic
How is Fe best given?
Oral Ferrous Sulphate, but only 25% of given is absorbed.
What are side effects of giving Fe?
GI upset
Constipation
Who is OD of Fe possible in?
Children
What are the symptoms of Fe OD in children?
Necrotising Gastroenteritis, pain, blood and shock.
What is extrinsic factor necessary for?
Absorbing B12
Where is B12 absorbed?
Ileus
What is pernicious anaemia?
Absence of intrinsic factor so no B12 absorbtion
What is B12 essential for and what are the implications?
DNA synthesis meaning that deficiency results in abnormal RBCs and MEGALOBLASTIC anaemia- large fragile RBCs
What are the other symptoms of B12 deficiency?
Fatty deposits on neuronal membranes causing Wernicke and Korsakoffs
How is B12 deficiency treated?
Thiamine injections
Can you get folic acid or B12 toxicity?
No
How is folic acid given?
Orally