Anaemia drugs Flashcards

1
Q

What does erythropoiesis require?

A

Iron
Vit B12
Folic Acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What aspect of blood is Fe needed for

A

Haemoglobin production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does Fe deficient anaemia look like?

A

Microcytic Hypochromic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is Fe best given?

A

Oral Ferrous Sulphate, but only 25% of given is absorbed.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are side effects of giving Fe?

A

GI upset

Constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Who is OD of Fe possible in?

A

Children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the symptoms of Fe OD in children?

A

Necrotising Gastroenteritis, pain, blood and shock.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is extrinsic factor necessary for?

A

Absorbing B12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where is B12 absorbed?

A

Ileus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is pernicious anaemia?

A

Absence of intrinsic factor so no B12 absorbtion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is B12 essential for and what are the implications?

A

DNA synthesis meaning that deficiency results in abnormal RBCs and MEGALOBLASTIC anaemia- large fragile RBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the other symptoms of B12 deficiency?

A

Fatty deposits on neuronal membranes causing Wernicke and Korsakoffs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is B12 deficiency treated?

A

Thiamine injections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Can you get folic acid or B12 toxicity?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How is folic acid given?

A

Orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does erythropoietin do?

A

In hypoxia or blood loss it stimulates increased haemoglobin synthesis and erythrocyte release.

17
Q

How is deficiency of erythropoietin treated?

A

Synthetic hormone IV or S/c for anaemia in chronic renal failure