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Pharma > Antiemetics > Flashcards

Antiemetics Flashcards

1
Q

What is vomiting controlled by?

A

Chemoreceptor trigger zone (CTZ) in Medulla

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2
Q

What receptors are present in the CTZ that can cause vomiting?

A

D2

5HT3

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3
Q

What receptors does the medulla have that can cause vomiting?

A

Muscarinic

Histamine

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4
Q

What is unique about the CTZ?

A

Not protected by BBB

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5
Q

What dopamine D2 antagonists are antiemetics?

A

Metoclopramide (prokinetic)
Domperidone (doesnt cross BBB so no drowsiness)
Prochloperazine

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6
Q

What 5HT3 antagonists are used as antiemetics?

A

Ondansetron

Granisetron

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7
Q

When are 5HT3 antagonists used?

A

As an add on in drug induced emesis

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8
Q

What antimuscarinics is used and what for?

WHat are SEs?

A

Hyosine (motion sickness)

Dry mouth, blurred vision

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9
Q

What antihistamines are used?

A

Cyclizine

Promethazine

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10
Q

What are antihistamines used for?

A

Menieres Disease

Motion sickness

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