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Pharma > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

What are the properties of NSAIDs?

A

Analgesic
Antipyretic
Anti-inflammatory (high dose)

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2
Q

What is the mechanism of action of all NSAIDs?

A

COX Inhibitors which means prostaglandin synthesis is inhibited (bradykinin and histamine inactivated)

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3
Q

Name some NSAIDs

A 
Ibuprofen
Aspirin
Naproxen
Diclofenac
Indometacin
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4
Q

What would you use for inflammatory joint disease?

A

Ibprofen

Naproxen

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5
Q

What would you use for post-op pain?

A

Diclofenac

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6
Q

What are the side effects of NSAIDs?

A

GI tract- COX-1 stimulates PGE 1 and PGI2 which stimulate mucous and bicarb secretion to protect gastric mucosa. NSAIDs block COX 1 leading to bleeding and ulceration. PPIs protective
Nephrotoxic- In the absence of COX 1 there is Na retention and decreased blood flow leading to renal failure (especially in cirrhosis or CCF) as normally it causes vasodilation.
Chronic NSAID use= chronic renal failure

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Pharma (22 decks)

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