Antihypertensives Flashcards
How do ACEis work?
Vasodilators
Decrease circulating angiotensin II therefore reducing peripheral resistance.
What are SEs of ACEi?
Bradykinin dry cough
Angioedema (rare- usually Afro-Caribbean people)
When are ACEi contraindicated?
Renal Artery Stenosis and Renal Impairment
Name 2 ACEi
Ramipril
Enalapril
Lisinopril
What is Losartan?
An Angiotensin Receptor Antagonist
What are the advantages of Angiotensin antagonists over ACEi?
No cough but similar effectiveness
Name 2 Calcium channel blockers
Amlodipine
Nifedipine
How do CCBs work?
Vasodilators by causing relaxation of smooth muscles in vasculature
What are SEs of CCBs?
Ankle oedema
dizziness
Hypotension
What are the risks of using thiazides?
DM
Gout
Hypokalaemia
How do BBs work to reduce hypertension
Decrease Cardiac Output both speed and contractility
What are the side effects of BBs?
Cold hands and feet
ASTHMA PROVOKED
Increase blood lipids
Which BBs are used to be cardioselective in hypertension?
Atenolol
Bisoprolol
Metoprolol
Name a centrally acting antihypersensive that works on the sympathetic outflow
Methyldopa
