GI Motility Drugs

Question 1

What are metoclompramide and domperidone used for?

Answer 1

Motility stimulant in reflux and stasis and antiemetic

Question 2

How do Motility stimulants work?

Answer 2

They are dopamine antagonists, increasing gastric contractions and tone in the lower oesophageal sphincter which increases speed of gastric emptying.

Question 3

Name 2 motility stimulants

Answer 3

Metoclopramide

Domperidone

Question 4

Name the 3 types of laxative

Answer 4

Bulk
Osmotic
Stimulant

Question 5

How do bulk laxatives work and name one?

Answer 5

Increased volume of intestinal contents increases peristalsis
Cellulose

Question 6

How do osmotic laxatives work and name one

Answer 6

Increase bulk by encouraging water retention.
They are therefore made up of poorly absorbed salts like MgSO4
Lactulose

Question 7

How do stimulant laxatives work and name one

Answer 7

Act on the mucosal plexuses
Senna, Glycerol, Bisacodyl
SE: cramps

Question 8

What kind of laxative is

a) Senna
b) Cellulose
c) Lactulose

Answer 8

Stimulant
Bulk
Osmotic

Question 9

What drugs is used for anti- motility in the gut? Why is this useful?

Answer 9

Loperamide

Anti Diarrhoeal

Question 10

What is used to dissolve Gall stones?

Answer 10

Ursodeoxycholic acid