Pathology Flashcards
Infectious causes of granulomas
Mycobacteria, bartonella henselae (cat scratch), listeria (granulomatosis infantiseptica), tertiary syphillis, endemic fungi shistosoma
Autoimmune granulomatous diseases
sarcoid, Crohn, PBC, subacute thyroiditis, Churgh-Strauss, GCA, Takyasu, Wegener
Foreign material causing granulomas
Berylliosis, talcosis, hypersensitivity pneumonitis
Cancer associated with hypercalcemia
Squamous cell carcinomas of various organs (PTHrP) and lymphoma (calcitrol)
Cancer associated with Cushing and SIADH
small cell of the lung
Cancer associated with pure red cell aplasia and Good syndrome (hypogammaglobulinemia)
thymoma
Cancers assoc. w/ Trousseau and NBTE
adenocarcinomas, especially pancreatic
Cancers assoc. w/ anti-NMDA receptor encephalitis
ovarian teratoma
Cancers assoc. w/ opsoclonus-myoclonus ataxia syndrome (dancing hands, dancing feet)
neuroblastoma in kids, small cell lung cancer in adults
Cancers assoc. w/ paraneoplastic cerebellar degeneration (antibodies vs. Hu, Yo, and Tr in Purkinje cells)
small cell lung cancer, gynecologic and breast, Hodgkin lymphoma
cancers assoc. w/ paraneoplastic encephalomyelitis (antiboies vs. Hu in neurons)
small cell lung cancer
Cancers assoc. w/ lambert-eaton
small cell lung cancer
Cancer-causing HPV strains
16, 18
Psammoma bodies seen in…
papillary carcinoma of thyroid, serous papilary cystadenocarcinoma of ovary, meningioma, malignant mesothelioma
Breast cancer marker
CA 14-3/CA 27-29
Pancreatic adenocarcinoma marker
CA 19-9
Ovarian cancer serum marker
CA 125
Cytokines that mediate cachexia
TNF-alpha, IFN-gamma, IL-1, IL-6
Cancer assoc. w/ ALK onocogene
lung adenocarcinoma
Cancer assoc. w/ BRAF oncogene
melanoma, NHL
Cancer assoc. w/ KRAS oncogene
colon, lung, pancreatic
Cancer assoc. w/ MYCL1 oncogene
lung tumor
Cancer assoc. w/ MYCN oncogene
neuroblastoma
cancer assoc. w/ RET oncogene
MEN 2a and 2b, medullary thyroid cancer
cancer from loss of CDKN2A
melanoma, pancreatic cancer (p16, blocks G1 to S)
cancer from loss of DCC
colon cancer (Deleted in Colon Cancer)
cancer from loss of DPC4/SMAD4
pancreatic cancer (deleted in pancreatic cancer)
Cancer assoc. w/ aflatoxin
HCC
Cancer assoc. w/ aromatic amines
transitional cell carcinoma of bladder
Cancers assoc. w/ arsenic
liver angiosarcoma, lung cancer, squamous cell carcinoma of skin
Cancer assoc. w/ ionizing radiation
papillary thyroid carcinoma
Cancer assoc. w/ radon
lung cancer
cancer assoc. w/ vinyl chloride
liver angiosarcoma