Hematology and Oncology Flashcards
which platelet granules contain ADP and calcium
dense granules
which platelet granules contain vWF, fibrinogen, and fibronectin
alpha granules
which neutrophil granules contain LAP, collagenase, lysozyme, and lacteferrin
specific granules
which neutrophil granules contain proteinases, acid phosphatase, MPO, and beta-glucuronidase
azurophilic granules
what receptor on macrophages binds LPS lipid A
CD14
MOA cromolyn sodium
prevents mast cell degranulation, for asthma prophylaxis
components of Hb A
2 alpha, 2 beta
components of Hb A2
2 alpha, 2 delta
elevated in beta thal minor
components of fetal hemoglobin
2 alpha, 2 gamma
elevated in beta thal major
components of Hb H
4 betas, seen in 3 alpha deletions
components of Hb Barts
4 gamma, seen in 4 alpha deletions which causes fatal hydrops fetalis
which hemoglobin moves the farthest on electrophoresis, and which are behind
A goes the farthest, then F, then S, then C
which factors are inactivated by warfarin
II, VII, IX, X, C, S
protein C cleaves
V, VIII
acanthocyte (spur cell) assoc dz
liver disease, abetalipoproteinemia
degmacyte (bite cell) dz assoc
G6PD
echinocyte (burr cell) dz assoc
ESRD, liver disease, pyruvate kinase deficiency
note projections are more uniform and smaller than those of the spur cell
spherocyte dz assoc
hereditary spherocytosis, drug- and infection-induced hemolytic anemia
target cell dz assoc
HbC disease, asplenia, liver disease, thalassemia
“‘HALT,’ said the hunter to his target”
Heinz body dz assoc
G6PD deficiency. precursor the the bite cell
Howell-Jolly bodies dz assoc
aslpenia
microcytic anemias
late iron deficiency, late ACD, thalassemias, lead poisoning, sideroblastic anemia
normocytic, nonhemolytic anemias
early iron deficiency, early ACD, aplastic anemia, CKD
normocytic, intrinsic hemolytic anemias
RBC membrane defects (e.g. HS), enzyme defects (e.g. G6PD and PK), HbC disease, sickle cell, PNH
