Pagets Disease

Question 1

Pagets Disease Definition

Answer 1

• Metabolic bone disease caused by increased bone resorption followed by excessive unrestricted bone formation, due to activated osteoclasts
• This leads to bone instability which can lead to fractures, arthritis, deformities, and pain
• Second most common metabolic bone disease to osteoporosis

Question 2

Pagets Disease Cause

Answer 2

• Unknown (thought to be slow, viral bone infection due to risk factors include a gene-environment interaction)
• Seen in individuals older than 50 years
• Males = females
• Prognosis is good, especially if treated early (there is no cure but disorder can be controlled from progressing)

Question 3

Pagets Disease Clinical Presentation

Answer 3

• Pain involving bones and joints
• Diffuse joint stiffness
• Abnormally large skull
• Jaw deformity
• Loss of hearing
• Migraines / HA
• Fractures
• Heart failure
• Cranial nerve neuropathies

Question 4

Pagets Disease Diagnosis

Answer 4

• Bone scan
• Bone x-ray

Question 5

Pagets Disease Medications

Answer 5

• Biophosphates
• Pain relievers (analgesics)
• Calcium
• Vitamin D