Glucocorticoids

Question 1

Glucocorticoids Purpose

Answer 1

• Decrease inflammation by inhibiting release of pro-inflammatory molecules
• Starts in hypothalamus and sends negative feedback to anterior pituitary gland (which releases cortisol)
• Examples — cortisone, prednisone, triamicinolne, budesonide, dexamethasone

Question 2

Glucocorticoids Indications

Answer 2

• Hormone replacement therapy
• Inflammatory and autoimmune conditions (OA, RA, asthma, arthritis, allergies, etc)
• Other conditions such as MS and cancer

Question 3

Glucocorticoids Side Effects

Answer 3

• Hypothalamic-pituitary-adrenal (HPA) suppression — cortisol has inhibiting effect on ACTH which can lead to cushings (hypertension and hyperglycemia)
• Weight gain and muscle weakness
• Osteoporosis (prednisone)
• Hypercortisolism (cushings)
• Mood changes
• Effects patients with diabetes