Other Tumor Types Flashcards
Cutaneous Hemangiosarcoma
UV light induced
Inguinal and epidermal (doesn’t penetrate dermis)
Who is most likely to get cutaneous Hemangiosarcoma?
Lightly-haired glabrous skin
Dalmatians, pits, boxers, beagles, whippets
What is the difference in biologic behavior for cutaneous and visceral hemgiosarcoms in dogs?
??
Where is primary visceral HSA mostly found?
Spleen
Liver, right atrium and skin
Anywhere there are Bvs
Most common cardiac tumor
Presentation of visceral HSA
RHF- ascites
Weakness, lethargy, collapse, anemia with pale mm, waxing and waning
Differential dx of splenic masses
Hematoma
Hyperplasia
2/3 malignant and 2/3 HSA
How do you dx Hemangiosarcoma
Histopathology*
Cytology (+ if malignant cells)
Imaging (hypoechic, cavitary)
Clin path changes with Hemangiosarcoma
Anemia: regen if old bleed, non with acute bleeding
Thrombocytopenia
DIC (Exposure of endothelium)
Schistocytes
EKG changes with Hemangiosarcoma
Electrical alternans
Small complexes
What predisposes to injection site carcinoma?
Multiple Ags in the same Vx
Killed Vx
Adjuvanted vx
Which Vx should you use to avoid ISS
Monovalent, non-adjuvated, only necessary Vx, admin SQ not IM
What is the surgical recommendation to get complete margins in ISS?
Avoid interscapular space
Distal limb (allow for amputation)
Tail (more distal)
Sx for ISS
GP MTR= 2-3m
Boarded surgeon= 14m
Amputation
MST= 2y
Recurrence rate after sx for ISS
40-70% with MTR 6m despite clean margins
Signalment of transitional cell carcinoma of the bladder
Older dogs
Females predisposed
Scotties, WHWT, wire-haired fox terrier, shelties, beagles
TCC
Trigone of bladder
Field effect
>50% have urethra involvement
Urinary obstruction
Dx of TCC
Braf test: performed on free-catch urine combined sample 40mL and non invasive
FNA/traumatic catheter/sx: risk of seeding
Tx/ prognosis of TCC
Piroxicam: 6m, PR: 15-20%
Piroxicam + CT: 1y, PR= 33%
Vinblastine: 5m
RT: obstruction, 6m
Tx of AGASACA
Sx LNs: 2y with multiple Sx
Blind digital extirpation
Massive hepatocellular carcinoma
Mass
Diffuse hepatocellular carcinoma
Throughout the liver- met (more common, left lobe)
Why do we not expect CT to work well for liver tumors?
More chemo resistant: the liver clears toxins so most CT agents are considered toxins
What cats are predisposed to developing squamous cell carcinoma
White faced cats
How do we tx SCC in cats
Sx, Cryotherapy, RT, ECT, Imiquamod, PDT
Sunscreen
Prognosis fro cats with SCC?
Predisposed, high recurrence >60%
MST= 600 days
