Oncogenes and associated tumors

Question 1

PDGFB

Answer 1

platelet derived growth factor; over-expressed + autocrine loop in astrocytoma

Question 2

ERBB2 (HER2/neu)

Answer 2

epidermal growth factor receptor; amplification in subset of breast carcinomas

Question 3

RET

Answer 3

neural growth factor receptor; point mutation in MEN2A, MEN2B and sporadic medullary carcinoma of thyroid

Question 4

KIT

Answer 4

stem cell growth factor receptor; point mutation in Gastrointestinal stromal tumor

Question 5

RAS gene family

Answer 5

GTP-binding protein; point mutation in carcinomas, melanoma, and lymphoma

Question 6

ABL

Answer 6

tryosine kinase; t(9;22) with BCR in CML and some types of ALL

Question 7

c-MYC

Answer 7

transcription factor; t(8;14) involving IgH in Burkitt Lymphoma

Question 8

N-MYCM

Answer 8

transcription factor; amplification in Neuroblastoma

Question 9

L-MYC

Answer 9

transcription factor; amplification in Lung carcinoma (small cell)

Question 10

CCND1 (cyclin D1)

Answer 10

cyclin; t(11;14) involving IgH in Mantle cell lymphoma

Question 11

CDK4

Answer 11

cyclin-dependent kinase; amplification in Melanoma

Question 12

Growth factor oncogene

Answer 12

PDGFB (platelet derived growth factor receptor)

Question 13

Growth factor receptor oncogenes

Answer 13

ERBB2 (HER2/neu), RET, KIT

Question 14

Signal transducer oncogenes

Answer 14

RAS gene family, ABL

Question 15

Nuclear regulator oncogenes

Answer 15

c-MYC, N-MYC, L-MYC

Question 16

Cell cycle regulator oncogenes

Answer 16

CCND1 (cyclin D), CDK4