anti-arryhthmics Flashcards
Class IA anti-arrhythmics
Procainamide, Quinidine, Disopyramide
Class IB anti-arrhythmics
Lidocaine, Phenytoin, Mexiletine
Class IC anti-arrhythmics
Flecamide, Propafenone
Class III anti-arrhythmics
Sotalol, Amiodarone, Ibutilide, Dofetilide
Class II anti-arrhythmics
beta blockers
Class IV anti-arrhythmics
nondihydropiridone Ca channel blockers; verapamil + diltiazem
Extras
Digoxin, Magnesium, Adenosine, Ivabradine
Cause QT prolongation and risk of Torsades
Ia and III
Which QT prolonging drug doesn’t run risk of Torsades
Amiodarone
Which act on cardiac myocyte AP?
I and III
Which have effect of K+ of myocyte AP?
III and Ia
SE of adenosine
flushing, hypotension, CP, bronchospasm, feeling of doom
What is responsible for maintaining the electrochemical gradient at resting membrane potential?
Na/K ATPase
Ion responsible for node repolarization?
K
location of SA node
R atria
magnesium is used to treat what specific type of arrhythmia?
Torsades De Pointes
flushing, chest pain, dyspnea, hypotension
Adenosine SE
Which class Ia also blocks a -adrenergic and muscarinic receptors, thereby potentially leading to increased heart rate and AV conduction
quinidine
procainamide SE
lupus, N/V/D, agranulocytosis, thrombocytopenia
disopyramide SE
anticholinergic = urinary retention, dry eyes and mouth, blurred vision, constipation, sedation
what two antiarrhytmics can cause pulmonary fibrosis
tocainide + amiodarone