drugs

Question 1

What are the broad spectrum anti-epileptic meds?

Answer 1

Valproate, Topiramate, Lamotrigine, Levetiracetam

Question 2

valproate causes what type of terratogenic affect?

Answer 2

neural tube, like spina bifida

Question 3

Which antiepileptic drugs increase Na+ channel inactivation?

Answer 3

Topiramate, Valproate, lamotragine, carbamazepine, phenytoin

Question 4

How to valproate and topiramate affect weight?

Answer 4

t = lose, v = gain

Question 5

Which anti-epileptics cause SJS

Answer 5

lamotrigine, carbamazepine, phenytoin,

Question 6

List the narrow spectrum anti-epileptics - focal seizures and focal seizures with secondary generalization

Answer 6

Phenytoin, Carbamazepine, phenobarbital, gabapentin, vigabatrin, tiagabine

Question 7

Which drugs induced CYP450?

Answer 7

Topiramate, carbamazepine, phenytoin

Question 8

Treatment of which two types of seizures should be avoided with narrow spectrum?

Answer 8

JME and absance

Question 9

What is treatment protocol of status epilepticus?

Answer 9

benzo (lorazepam, diazepam) + phenytoin, add phenobarbitol if necessary

Question 10

which two antiepilectics work to potentiate affects of GABA?

Answer 10

vigabatrin, tiagabine

Question 11

what drugs can be used for absant seizures?

Answer 11

ethosuximide, valproate, lamotrigine

Question 12

what type of seizure has a SUPER characteristic EEG spike?

Answer 12

absant - 3 hz peaks

Question 13

List the 8 drugs used in parkinsons

Answer 13

levidopa, carbidopa, entacapone, tolcapone, selegiline, ropinirole, pramipexole, amantadine

Question 14

MOA of selegiline?

Answer 14

MAO-B inhibitor, increasing dopamine in CNS

Question 15

MOA of ropinirole?

Answer 15

D2 receptor agonist

Question 16

MOA of pramipexole?

Answer 16

D3 receptor agonist

Question 17

What sort of behavior does dopamine R agonists potenitalte?

Answer 17

addictive impulse behavior

Question 18

What two drugs are used to keep ACh levels in check, ie anti-muscarinic?

Answer 18

trihexyphenidyl and benzotropine

Question 19

Which COMT inhibitor works both in peripher and CNS

Answer 19

Tolcopone

Question 20

Which anesthetics are administered IV?

Answer 20

Propofol, etomidate, ketamine, benzodiazepine, phenobarbitol

Question 21

Which are used for induction phase of anesthesia?

Answer 21

propofol, etomidate, ketamine, thiopental

Question 22

which anesthesia is heart safe?

Answer 22

etomidate

Question 23

which rx causes dissassociative anaesthesia?

Answer 23

ketamine

Question 24

examples of volatiles anesthetics?

Answer 24

isoflurane, halothane, enflurane

Question 25

which inhaled anesthetic has low solubility and fastest on/off?

Answer 25

N2O

Question 26

what is synonymous with blood:gas partition coefficient?

Answer 26

solubility; higher = higher solubility = slower onset of action, slower off

Question 27

HIGHER solubility = _______ onset of action

Answer 27

slower

Question 28

MAC = ?

Answer 28

dose of anesthetic where 50% of patients become irresponsive to painful stimuli

Question 29

how is potency related to mac?

Answer 29

inversely