Olanzapine

Question 1

What is the Pharmacology of Olanzapine

Answer 1

Atypical Anti-psychotic

- Antagonist at multiple receptor sites, particularly serotonin (5HT3), dopamine and Histamine

Question 2

What is the Presentation of Olanzapine and how is it Metabolized.

Answer 2

Presentation
5mg ODT

Metabolized

Question 3

What are the Indications and Contraindications for Olanzapine

Answer 3

Indications
- Mild Agitation

Contraindications
- Nil of Significance

Question 4

What are the Side Effects and Precautions of Olanzapine

Answer 4

Side Effects (SED)
CNS
- Sedation 
- Dizziness
Other
- Extrapyrmidal symptoms and QT prolongation. 

Precautions

• Olanzapine is less effective if pt agitation is due to the effects of drug or alcohol intoxication, Especially (stimulants)
• Elderly and frail or children are more susceptible to adverse effects.

Question 5

Route of Administration and Special Notes

Answer 5

Route of Administration
- ODT

Special Notes

• Administration to pts less than 16 years of age should be consulted with the receiving hospital.
• Pts should self administer the medication under paramedic supervision.
• Olanazapine is managed as a restricted medication under AV policy.
• Olanzapine and Odansatron are similar in name and presentation, care should be undertaken when administering these medications.

Onset: 15 minutes
Duration: 12 - 24 Hours.