Aspirin

Question 1

What is Aspirins Pharmacology

Answer 1

Is a Analgesic, Antipyretic, anti-inflammatory and anti-platelet aggregation agent.
Actions
- To minimize platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombus formation in ACS.
- Inhibits synthesis of propaglandin. (Anti- inflammatory response).

Question 2

What is the presentation of Aspirin and how is it metabolized.

Answer 2

Presentation
- 300mg Chewable tablet. 
- 300mg water soluble tablet
Metabolized 
- Converted in salicylate in the gut mucousa. Excreted by the kidneys.

Question 3

What are the Indications and Contraindications for Aspirin

Contras (3 bloods, 2 Drugs)

Answer 3

Indications
- ACS

Contraindications (3 Bloods/ 2 Drugs)

• Bleeding Disorders
• Actively bleeding peptic ulcers
• Suspected dissecting aortic aneurysm
• Hypersensitivity to Aspirin/ Salicylate
• Chest pain associated with psycho stimulant overdose with a BP >160

Question 4

What are the Side Effects/ Precautions for Aspirin.

Side Effects (HHING)
Precautions (PAP)

Answer 4

Side Effects (HHING)

• Increased bleeding time.
• Hypersensitivity reactions
• Heartburn, Nausea and GI bleeding

Precautions (PAP)

• Peptic ulcers
• Asthma
• Patients on Anticoagulants

Question 5

Special Notes

Answer 5

• Aspirin is Contraindicated for use in acute febrile illness in Children and Adolescents
• The anti-platelet effects of aspirin persist for the natural life of platelets.
  Duration: 8 - 10 days