Odansetron

Question 1

What is the Pharmacology of Odansetron

Answer 1

Anti-emetic

5HT3 receptor antagonist which blockers receptors centrally and peripherally.

Question 2

What is the Presentation of Odansetron and how is it Metabolized

Answer 2

Presentation

• 4mg ODT
• 8mg in 4ml IV solution

Metabolized
- By the Liver.

Question 3

What are the Indications and Contraindications of Odansetron

Answer 3

Indications

• Undifferentiated nausea and vomiting.
• Prophylaxis in spinally immobilized or eye injured pts.
• Vestibular nausea in pts < 21 years of age (Contraindicated for Stematil)

Contraindications (Odans dance)

• Hypersensitivity to Odansetron
• Hypokalemia (Low Potassium) Hypomagnesemia (low magnesium)
• Long QT syndrome
• Concurrent use of ApoMorphine (Parkinson’s Medication)

Question 4

What are the Side effects and Precautions of Odansetron

Answer 4

Side Effects (CHEFD Common) 
Common 
- Constipation
- Headache
- Rise in liver Enzymes
- Fever
 - Dizziness

Uncommon (WTSHEEP)

• Wide QRS complex
• Tachyarrythmias
• Seizures
• Hypersensitivity reactions
• Extrapyrmidal reactions
• Eyes (Visual Disturbance)
• Prolongation of Qt segment

Precautions (LEAPT)

• Pts with liver disease shouldn’t receive more than 8mg of Odansetron a day.
• Care should be taken with pts on diuretics who have underlying electrolyte imbalances.
• Concurrent use of Tramadol
• Pregnancy
• Ondansatron contains Aspartamne and should not be given to patients with Phenylketouria.

Question 5

Route of Administration and Special Notes

Answer 5

Route of Administration

• ODT
• IV

Special Notes
IV doses should be pushed as a slow does (minimum of 30 seconds) due to potential of adverse effects.

ODT effects
- Onset: 2 Minutes
- Peak: 20 Minutes
- Duration: 2 Hours
IV
- Onset: 5 minutes
- Peak: 10 Minutes
- Duration: Between 2.5 and 6.1 Hours.