Midazalam

Question 1

What is the Pharmacology of Midazalam

Answer 1

Midazalam is a Benzodiazapine the acts on GABA A (Inhibitory Receptors).

• Short Acting CNS depressant
  
  • Anxiolytic
  • Sedation
  • Anti-convulsant.

Question 2

What is the Presentation of Midazalam and how is it Metabolized

Answer 2

Presentation of Midazalam

• 5mg in 1ml
• 15mg in 3ml.

Metabolized.
- In the Liver and Excreted by the Kidneys

Question 3

What are the Indications and Contraindications of Midazalam.

Answer 3

Indications

• Status Epileptics
• Sedation in the Agitated patient.
• Sedation in Psycho stimulant OD
• Sedation to maintain intubation
• Sedation to Facilitate RSI
• Sedation to Facilitate Synchronized Cardioversion
• Sedation to Facilitate transthrosic pacing

Contraindications
- Hypersensitivity to Benzodiazapines.

Question 4

What are the Side Effects and Precautions of Midazalam

Side effects (HARD)

Answer 4

Side Effects (HARD)

• Resp Depression
• Depressed level of Consciousness
• Hypotension
• Loss of Airway Control

Precaution (CAME)

• Reduce Doses may be required for
• Elderly and frail pts with chronic renal failure, CCF or Shock.
• Can cause severe Respiratory Depression with pts who suffer from COPD
• Pts with myasthania Gravis
• The CNS depressants of Benzodiazpines are enhanced by other drugs like narcotics or tranquilizers, e.g Alcohol.

Question 5

Route of Administration and Special Notes

Answer 5

Route of Administration

• IM
• IV
• IV Infusion

Special Notes
IM 
- Onset: 3 - 5 Minutes
- Peak: 15 Minutes
- Duration: 30 Minutes 
IV
- Onset: 1 - 3 Minutes
- Peak: 10 Minutes
- Duration: 20 Minutes