Methoxyflurane

Question 1

What is the Pharmacology of Methoxyflurane

Answer 1

Inhaled Analgesic agent at low doses.

Question 2

What is the Presentation of Methoxyflurane and how is it Metabolized.

Answer 2

Presentation
- 3ml

Metabolized
- By the liver and Excreted by the lungs.

Question 3

What are the Indications and Contraindications of Methoxyflurane.

Contraindications (MRCHE)

Answer 3

Indications
- Pain Relief

Contraindications (MRCHE)

• Muscular Dystrophy
• Pre- Existing Renal Impairment or Disease.
• Concurrent use of Tetracycline Antibiotics.
• Family Hx of Malignant Hyperthermia
• Exceeding the Max Dose of 6ml in 24 Hours.

Question 4

What are the Side effects and Precautions of Methoxyflurane

Side Effects (HED)

Answer 4

Side Effects (HED)

• Drowsiness
• Hypotension/ Bradycardia (Rare)
• Exceeding the total does may lead to renal Toxicity,

Precautions.

• The Penthrox inhaler must be held by the patient, therefore if unconsciousness occurs it will fall from the patients mouth.
• Pre-eclampsia
• Concurrent use of oxytocin may cause hypotension.

Question 5

Route of Administration and Special Notes

Answer 5

Route Of Administration
- Inhaled

Special Notes

• 3mls will provide 25 minutes of Analgesia, it may be followed by another 3mls if appropriate.
• Analgesia occurs after around 8 - 10 breaths, and last for 3 - 5 minutes if Discontinued.
• Do not Administer in an enclosed space, allow adequate ventilated area.
• Malignant Hyperthermia is a rare condition and can be induced by some anesthetics including Methoxyflurane. Ask patients about a family history or past history of adverse reactions to inhaled anesthetics.
• In patients with MD, Anesthetics may precipitate life threatening rhabdomyolysis