OB/GYN Flashcards
What labs/studies should you get in evaluating new diagnosis of pregnancy?
• UPT
• Serum pregnancy test
• UA and culture
• ABO
• TVUS
Other than the obvious complaints that would make you suspicious for pregnancy – like missed period, vaginal bleeding – what other things should prompt a UPT?
GI complaints: abdominal pain, vomiting, nausea, constipation/diarrhea
GU complaints: dysuria, UTI, urinary urgency, vaginal discharge
Neuro complaints: headache, sleep trouble
Cardiovascular: HTN, dyspnea
Constitutional: weight gain, fatigue
A 1st trimester pregnant woman presents with vaginal bleeding. What workup do you order?
CBC (blood loss)
UA (UTI)
G/C swab (infection as a trigger of AUB)
ABO (if they are Rh-negative then Rhogam may be indicated)
Serum bHCG and TVUS for ectopic r/o
If you are concerned about pregnancy and the UPT is negative, what are your options for follow-up?
Repeat UPT in one week (if no concern for acute complications)
Serum bHCG (more sensitive that UPT)
What (non-pregnancy) OB emergency do you need to remember every time you see a woman with abdominal pain?
Ovarian torsion: Abrupt onset pain. Can be on/off (due to torsion-detorsion). Usually unilateral lower quadrant. Pain on bimanual exam.
What two drugs treat chlamydia?
Doxycycline
Azithromycin
Due to rising rates of resistance to azithromycin, doxycycline is now first line.
True or false: US is sensitive for detecting placental abruption.
False
It can catch it but has poor sensitivity. If you are suspicious for abruption (based on abdominal pain, vaginal bleeding, and history of cocaine/trauma/HTN), then consult OB/GYN for further assessment.
If a woman presents with a concerning story for ovarian torsion and the US is negative, what should you be thinking of?
Intermittent torsion
A negative US only tells you that there was no torsion when the study was done. Particularly if her pain resolved or abated when the study was done.
What increases risk of ovarian torsion?
Masses on the ovaries – particularly cysts and teratomas
What two aspects of the primary survey are affected by pregnancy?
- Hypervolemia in the third trimester can mean that pregnant women can lose more blood without tachycardia or hypotension
- Pregnant women have physiologic respiratory alkalosis so a “normal” PCO2 can signify respiratory distress.
The normal WBC in pregnant women is ______________ (increased/decreased) compared to non-pregnant women.
increased
The normal range is 5-12 in pregnant women.
How is the pH buffer system different in pregnant women?
Pregnant women have a physiologic respiratory alkalosis with normal arterial pH 7.40 - 7.45, normal PaCO2 25-30, and normal bicarb 17-22.
Fibrinogen is _____________ (increased/decreased) in pregnancy.
increased
Normal range is 400-450 in the third trimester (compared to normal of 150 - 400 in non-pregnant women).
Blood pressure is physiologically _______________ (increased/decreased) in the second trimester.
decreased
It returns to normal by term.
True or false: ectopic beats during pregnancy warrant workup for peripartum cardiomyopathy.
False
Ectopic beats are common in pregnancy and only warrant workup if significantly symptomatic.
True or false: BUN rises during the third trimester.
False
Creatinine and BUN fall to about 1/2 their pre-pregnancy levels during pregnancy.
Glucosuria warrants what workup in pregnancy?
None
Glucosuria is a common physiologic finding in pregnancy and doesn’t warrant workup by itself.
Why do you need to assess the type of seatbelt used by pregnant women in MVCs?
Lap belts increase risk of placental abruption
Pregnant women getting intubated from traumas should have early placement of ________________.
naso/orogastric tubes to decrease the stomach, because the gravid uterus pushes up on the stomach and delays gastric emptying – both of which increase risk of aspiration
In the setting of a maternal trauma, what signs on FHR indicate urgent obstetrical intervention?
- Sustained abnormal FHR
- Repetitive decelerations
- Absence of accelerations
- Absence of beat-to-beat variability
Pregnant trauma patients should be evaluated for what pregnancy-specific treatment?
Rh immunoglobulin
Give this to all Rh-negative patients.
If a woman is at term and is having irregular contractions and she is < 4 cm dilated, then you should recommend what disposition?
Discharge and reassess when contractions become regular
If contractions are regular and the woman is 4-5 cm, then you can have her walk around and reassess.
If contractions are regular and the woman is 6 cm or more dilated then admit for labor.
What three tests assess ROM?
Pooling on SSE
Nitrazine
Ferning
A woman presents with third trimester vaginal bleeding. What do you need to make sure of before you do a SVE?
Ensure she does not have previa
For FHR variability, what are the parameters for the following:
- Absent
- Minimal
- Moderate
- Marked
- Absent: 0 BPM
- Minimal: 0-5 BPM
- Moderate: 6-25 BPM
- Marker: > 25 BPM
An acceleration is defined as _______________.
15 BPM above baseline for 15 seconds (if 32 weeks or greater) or 10 BPM above baseline for 10 seconds (if less than 32 weeks)
What is a late deceleration?
When the FHR decreases with a nadir that is after the peak of the contraction.
What things can help late decelerations?
- Turn down/off Pitocin
- Mom on L side
- Maternal oxygen
Review VEAL CHOP.
- Variable decelerations are Cord compression
- Early decelerations are Head compression
- Accelerations are Ok
- Late decelerations are Placental insufficiency
When the deceleration reaches its nadir at the same time as the contraction peak, it’s called an _______________.
early deceleration
When the deceleration reaches its nadir at variable times as the contraction peak, it’s called _______________.
variable contractions
What makes category I tracings?
All of the following:
- Baseline 110 - 160 BPM
- No variable or late decelerations
- Moderate variability
What makes category III tracings?
Any of the following:
- Bradycardia
- Absent variability
- Recurrent late or variable decelerations
What makes category II tracings?
Not meeting the category I tracings but not having any category III features.
The generic name of Hemabate is ____________.
carboprost
The generic name of Cytotec is _____________.
misoprostol
The generic name of Methergine is ___________.
methylergonovine
What are the criteria needed for AROM?
Active phase of labor (6 cm or greater and regular contractions) and station 0 or lower
When is GBS treatment needed?
- Positive in the last 5 weeks
- Unknown with risk factors (less than 37 weeks, prior infant with GBS disease, or ROM > 18 hrs)
What are the treatments options for chorioamnionitis?
- Ampicillin and gentamicin if vaginal delivery
- Ampicillin, gentamicin, and clindamycin if LTCS
Why should you start progesterone-only containing oral contraceptives in the postpartum period (as opposed to combined OCPs)?
Pregnancy is a clotting risk and the estrogen in combined pills would be too much of a DVT risk.
Why does gestational diabetes usually go away quickly after delivery?
Gestational diabetes happens because of human placental lactogen, a hormone made by the placenta. This hormone increases maternal insulin resistance to drive up maternal blood sugar so that babies get adequate glucose delivery.
The _______________ test is used to determine how much fetal-maternal blood mixing has happened in a trauma, delivery, or first-trimester bleed.
Kleihauer-Betke
A _______________ appears as a hypoechoic crescent between the gestational sac and the uterus.
subchorionic hematoma
Subchorionic hematoma raises the risk of what adverse outcomes?
- Spontaneous miscarriage
- Preterm labor
- PROM
- Placental abruption
Why should you evaluate for prolapse (with a Valsalva exam) for a post-menopausal woman with AUB?
Pelvic organ prolapse (POP) can cause AUB from irritation to the cervix and fornices that leads to AUB.
True or false: US is needed to diagnose endocervical polyps.
False
They usually are visible on SSE.
A woman who is in her first trimester with transaminitis and thrombocytopenia. Why should you be skeptical about the diagnosis of HELLP?
HELLP usually occurs in the third trimester
Describe the diagnosis of vulvodynia.
This is a rule-out diagnosis of vaginal pain. The diagnostic criteria are chronic vulvar pain (3 months or more) often described as burning in the setting of a normal physical exam and negative infectious workup (UA, wet prep, KOH prep).
The buzz words are “can’t wear tight pants” and positive Q-tip test. The Q-tip test is when a woman has sharp pain with gentle application of a Q-tip to the vulva.
What defines a prolonged second stage of labor? That is, what defines arrest of descent?
- Nulliparous women without epidural: 3 hours
- Nulliparous women with epidural: 4 hours
What antiepileptics should women on OCPs not take?
Any that increase cytochrome P-450: phenytoin and carbamazepine
Increased cytochrome P-450 leads to the increased breakdown of OCPs and the loss of their effectiveness. This is especially worrisome since both of the above lead to increased risk of NTDs.
Review the management algorithm for breast masses.
- Women younger than 30: US first. If complex then biopsy. If cyst then can offer drainage.
- Women older than 30: mammogram first. If complex then biopsy.
Other than pregnancy test, what is the first set of tests for secondary amenorrhea?
TSH, FSH, LH, and estrogen
This can rule out thyroid dysfunction, prolactinemia, and primary ovarian failure.
Which kind of IUD is associated with increased vaginal bleeding?
Copper
What are risk factors for adenomyosis?
- Age greater than 40
- Uterine surgery
- Multiparity
List two different regimens for partpartum endometritis.
- Most common: clindamycin and gentamicin
- Unasyn and gentamicin
The big picture is you want anaerobic coverage and broad spectrum coverage.
Note: chorioamnionitis is less associated with anaerobic infections so ampicillin and gentamicin is the first line therapy.
The most significant risk factor for postpartum endometritis is _____________.
C-section, particularly after a trial of labor
True or false: valproate is the least teratogenic of all the AEDs.
False
It is the most teratogenic.
Why should you never change seizure medicines during pregnancy?
Seizures are very bad for fetuses. They increase risk for preterm labor, placental abruption, and miscarriage. IF you switch medicines you increase risk of seizure. Furthermore, by the time most women discover that they are pregnant organogenesis has already occurred and the damage is likely to be done.
True or false: women on antiepileptics should not breastfeed.
False
Some AEDs can pass into the breastmilk and cause symptoms in the infant (like benzodiazepines or phenobarbital), but the benefits to breastfeeding usually outweigh the side effects to baby.
Why is mammography the standard evaluation tool for breast masses in women older than 30 but US is the standard for women younger than 30?
Denser breast tissue (which younger women tend to have) causes a higher rate of false-positive mammograms.
HELLP can also occur in the __________ period.
postpartum
True or false: IUD has the best typical-use pregnancy prevention rate.
False
Progestin implants are more successful.
How long do progestin implants last?
3 years
In addition to post-menopausal women, lichen sclerosus also affects ____________.
pre-pubertal girls
Pregnant women who have GBS bacteriuria should be treated ______________.
with amoxicillin for the bacteriuria and with penicillin during labor
How does pregnancy affect the symptoms of appendicitis?
It causes upward displacement of the appendix.
What can cause false-positive cell-free DNA?
Demised twin
Placental mosaicism
Recent blood transfusion
PCOS causes __________ testosterone and ___________ estrogen.
elevated; elevated
The first-line treatment for PCOS is ___________.
weight loss
Second-line therapies:
- OCPs for menstrual irregularity
- Letrozole for fertility
Letrozole has what mechanism of action?
Aromatase inhibition
How does letrozole help with fertility in those with PCOS?
Letrozole is an aromatase inhibitor. Aromatase converts androgens to estrogen. Inhibiting this enzyme leads to decreased circulating estrogen which improves ovulation in women with PCOS.
In addition to amenorrhea, women with functional hypothalamic amenorrhea (from strenuous exercise or calorie restriction) are likely to have what problem that requires medical intervention?
Bone mineral loss (give vitamin D and calcium)
What is the generic name of Plan B?
Ulipristal
How does ulipristal work?
It is a progesterone inhibitor.
What medicines need to be considered for women presenting after sexual assault?
PID meds (ceftriaxone and a macrolide or doxycycline) if she has signs of PID.
HIV meds (typically tenofovir-emtricitabine-raltegravir)
HBV meds if unvaccinated
HIV prophylaxis can be offered up to ________ hours after intercourse.
72
If a woman has had documented anaphylaxis to penicillin, she should get what for syphilis in pregnancy?
Penicillin desensitization
If she fails this then she can get ceftriaxone or a macrolide, but those are less studied than penicillin and should only be given in desensitization failure.
How should you manage a laboring woman who is discovered to have extensive vaginal warts?
Normal vaginal delivery
Although HPV lesions during delivery carry a small risk of respiratory papillomatosis in the child, it is not significant enough to warrant cesarian or other management.
Describe ovarian hyperstimulation syndrome (OHSS).
OHSS is a rare side effect of fertility treatment. It occurs 1-2 weeks after. woman has received exogenous hCG. The hormone hCG induces fluid shifts that lead to ascites, intravascular volume depletion, and in severe cases multiorgan failure.
Describe ovarian hyperstimulation syndrome (OHSS).
OHSS is a rare side effect of fertility treatment. It occurs 1-2 weeks after. woman has received exogenous hCG. The hormone hCG induces fluid shifts that lead to ascites, intravascular volume depletion, and in severe cases multiorgan failure.
Any woman with an EF less than ______ should be advised that pregnancy is not recommended due to high risk of maternal death.
40
The fluid shifts and increase in SVR in the postpartum period frequently lead to HFrEF exacerbations in women with CHF that can be fatal.