NSAID Flashcards

1
Q

Hvad er nsaids virkningsmekanisme?

A

Stopper cox-1 og cox-2 så de ikke kan omdanne arakidonsyre til hhv theomboxan a2, PGI2, PGE2 og Prostaglandiner

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2
Q

Hvor virker nsaids?

A

Centralt og perifert

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3
Q

Hvad er biotilgængelighed, proteinbinding, elimination pg metabolisme?

A

PO: 70-100%
PB: +99% lille Vd
Lever fase 1 og 2
Metabolitter i urin

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4
Q

Hvad er indikationer for nsaid? 7

A
Aseptiske inflammationer
Kolik
Spasmer i GI
Viscerale smerter
Aseptisk infektion i beværeapparat
MMA
Pneumonier(actinobacillus pleuropneumoniae)
Endotoksikoser
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5
Q

Hvad er ulemper ved nsaid?

A

Venteikelulceration
Forstyrret nyrefunktion
Forlænger drægtighed

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6
Q

Hvad sker der ift ventrikelulceration?

A

Mucuslag og beskyttelse mod mavesure. Forstyrret blodpladefunktion: hæmmer koagulation (cox1)

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7
Q

Hvordan manifesterer forstyrret nyrefunktion sig ved brug af nsaid?

A

Nedsat Renault blodflow og GF
Øger virkning af ADH
Øger absorption af cl
Øger K reabsorption

Husk ift hjertemidler og diuretika

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8
Q

Hvad er kontraindikationer ved brug af nsaid?

A
GI inflammation
Høj/hyppig dosering
Meget ung/gammel
Nefrir/nefrose
Dehydrering
Corticosteroider
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9
Q

Hvor findes thromboxan a2?

A

Platelets

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10
Q

Hvor findes PGI2?

A

Endorhelium

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11
Q

Hvor er PGE2?

A

Nyre

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12
Q

Hvor er der Prostaglandiner ?

A

Makeofager

Synovialceller

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13
Q

Hvilke nsaids er specifik cox 2?

A

Meloxicam
Firocoxib
Carprofen

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14
Q

Hvad er det nu med det der acetaminophen?

A

Nsaid men ikke cox hæmmer

Påvirker endoperoxid intermediater

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15
Q

Hvad er nsaids 3 virkningsområder?

A

Antipyretisk
Analgetisk
Antiinflammatorisk

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