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CLINICAL CHEMISTRY > NPNs: Uric Acid > Flashcards

NPNs: Uric Acid Flashcards

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1
Q

Major Product of Purine Catabolism

A

Uric acid

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2
Q

Purine is made from

A

Guanine + Adenine (PURGA)

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3
Q

Pyrimidine

A

pCUT

Pyrimidine = Cytosine, Uridyl, Thymine

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4
Q

Formed from xanthine oxidase from liver and intestine

A

Uric acid

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5
Q

Uric acid exist as _________ urates in plasma

A

Monosodium urates

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6
Q

> 6.8 g of urate crystals may form

A

Precipitate in tissues (gout arthritis)

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7
Q

Organic Meat
Legumes
Plant

A

High Purine Food

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8
Q

Confirms and Monitor Gout

A

Uric acid

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9
Q

diagnosis of Renal Calculi using Uric Acid uses what specimen

A

Urine

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10
Q

Uric acid can be used to monitor Uric Acid Nephropathy in cancer patient that undergoes chemotherapy

A

Yes

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11
Q

Uric Acid Crystals:

Reference Value
Male
Female

A

Male 3.5-7.2 mg/dL
Female 2.6-6.0 mg/dL
Urine 250-750 mg/day

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12
Q

Gout
Increased Nuclear Metabolism
Chronic Renal Disease
Lesch Nyhan Syndrome

A

Hyperuricemia

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13
Q
  • Occurs in male between 3rd and 5th decade of life
  • Negative birefringence crystals in synovial fluid
  • acute inflammatory arthritis
  • can lead to nephrothiliasis
A

Gout

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14
Q

Seen in leukemia, Lymphoma, MM and PV, Hemolytic and Megaloblastic Anemia

Treatment: Allupurinol

A

Increased Nuclear Metabolism

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15
Q

Decreased GFR and tubular secretion
BUA >10 mg/dL

A

Chronic Renal Disease

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16
Q

Inborn Error of Purine Metabolism

A

Lesh-Nyhan Syndrome

17
Q

Orange sand diaper syndrome ; deficiency of HGPT (Hypoxanthine Guanin Phosphoribosyl Transferase

A

Lesh-Nyhan Syndrome

18
Q

Seen in patient with Preeclampsia

A

Inc. BP
Inc. Protenuria
Inc. Uric Acid

19
Q

Treatment for Hyperuricemia:

Inhibits xanthine oxidase activity ; lowering UA in serum without affecting excretion in kidney

A

Allopurinol

20
Q

Treatment for Hyperuricemia:

Drugs that lower the serum UA but increase excretion of UA in urine = Prone to uric acid stones if not maintained at Alk pH.

A

Uricosuric drugs (Probenecid and Sulfinpyrazone)

21
Q

Treatment for Hyperuricemia:

  1. Neither excretion nor production is affected
  2. Alters phagocytic effect of leukocytes in uric acid crystals in tissues
  3. used in symptomatic patients
A

Colchicine

22
Q
  1. Fanconi Syndrome
  2. Wilson’s disease
  3. Hodgkin’s disease
  4. Overtreatment of Allopurinol
  5. Chemotherapy with azathioprine / 6-mercaptopurine
  6. Liver Disease
A

Hypouricemia

23
Q

Laboratory Methods for Uric Acid:

Chemical Method that uses
Principle: Redox Reaction

A

Caraway Method / Phosphotungstic Acid Method

24
Q

Laboratory Methods for Uric Acid:

Product produced in Caraway Method / Phosphotungstic Acid Method

A

Tungsten BLUE + ALLANTOIN + CO2

25
Q

Laboratory Methods for Uric Acid:

Enzymatic Method for Uric Acid (Blauch and Koch) uses the principle of

A

UV Spectrophotometry

26
Q

Laboratory Methods for Uric Acid:

Enzymatic method used in Uric Acid

A

Blauch and Koch

27
Q

Laboratory Methods for Uric Acid:

In Enzymatic Method for Uric Acid (Blauch and Koch) measures the ; product (?)

A

Decreased in absorbance at 293 nm

28
Q

Laboratory Methods for Uric Acid:

In Enzymatic Method for Uric Acid (Blauch and Koch) uses enzyme

A

Uricase

29
Q

Specimen used for Uric Acid Tests:

A

Heparinized Plasma
Serum or Urine

30
Q

Specimen used in Uric Acid Tests are stable for at

A

3 days ; Room Temperature

31
Q

Interference in Uric Acid Tests:

LBH
Lipemia, Bilirubin, Hemolysis

A

False Decrease

32
Q

Interference in Uric Acid Tests:

Salicylates and thiazides

A

False Increase

CLINICAL CHEMISTRY (29 decks)

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