Endocrine: Adrenal Cortex (Aldosterone) Flashcards
Most potent mineralocorticoid synthesized by Zone Glomerulosa
Aldosterone
Promote water and Na reabsorption to maintain normal blood pressure and blood salt concentration
Aldosterone
Aldosterone is synthesized by
G cells
Aldosterone is regulated by
RAAS system
Aldosterone acts on ____ for reabsorption Na and Cl excretion of K and H
Distal Convulated tube
Excess aldosterone excretion
Hyperaldosteronism
Plasma Aldosterone and Plasma Renin Activity
Volume status
Supine or upright position
Dietary Sodium Intake
Laboratory Measurement for HyperaldesteronismC
Characterized with DECREASED RENIN and Increased Aldosterone
Primary hyperaldosteronism
Normal Aldosterone and Renin Activity
Both Increased
PA/PRA >25
Primary Hyperaldosteronism / Conn’s Syndrome
Conn’s Syndrome Diagnosis Test
- Urine potassium Excretion
- Unprovoked hypokalemia
- CAPTOPRIL SUPPRESSION
- Level of 17-hydroxycortisone
- Adrenal imaging (CT or MRI)
- Adrenal Vein Sampling
Confirmatory Test for Conn’s Syndrome (Hyperaldosteronism)
Captropril Suppresion Test
Intake 50 mg captopril
PA remains high for 3 hrs; PA/PRA >25 before and after
Level of 17-Hydroxycorticosterone:
> 100 ng/dL =
Aldosterone producing ADENOMA
Level of 17-Hydroxycorticosterone:
<100 ng/dL =
Idiopathic hyperaldesteronism
Test for Hyperaldesteronism used to differentiate unilateral and bilateral hyperplasia
Adrenal Vein sampling
