Endocrine: Adrenal Gland Flashcards
located above the kidney, shaped like pyramids
Maintain BP, Na, K, Glucose hemeostasis
Adrenal Gland
treated with exogenous hormone replacement
Hypofunction
Treated with supressive drugs and surgery
Hyperfunction
Adrenal composed of 2 Glands
Adrenal Cortex (OUTER)
Adrenal Medulla (INNER)
Arise from mesenchymal cells with 3 zone layer
Adrenal Cortex
3 zone layer of Adrenal Cortex
- Glomerulosa (G-cell)
- Fasciculata (F-cell)
- Reticularis (R-cell)
Mineralocorticoid
Aldosterone
Salt
Glomerulosa (G-cell) (10%
Glucocorticoids
Glucose
Cortisol
Fasciculata (F-cell) (75%)
DHEAS
Sex steroids
Reticularis (R-cell) (10%)
stimulate production of Epinephrine
Glucocorticoids
arise from neural crest
Adrenal Medulla
Major Hormones involved in Hypothalamic Pituitary Axis
ACTH and Angiotensin
CRH
Cortisol
Major Substrate precursor for Adrenal Cortex
Cholesterol
Cholesterol is derived from (2)
- from LDL
- from Acetyl CoA
Zonal Glomerulosa Urinary Metabolite
17-hydroxycorticosteroids