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CLINICAL CHEMISTRY > Endocrine: Adrenal Cortex (Cortisol) > Flashcards

Endocrine: Adrenal Cortex (Cortisol) Flashcards

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1
Q

Affects blood pressure, glucose abnormalities
NEO, LY, GLY

A

Cortisol

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2
Q

Main glucocorticoids
Most abundant adrenal hormone

A

Cortisol

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3
Q

Second most abundant adrenal hormone

A

DHEA

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4
Q
  1. Cortisol is stimulated by adrenocorticotropic hormone
  2. Diurnal Pattern
  3. Stress
A

Factors Affecting Cortisol Secretion

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5
Q

Urinary Metabolite:

Method: Porter Silber Method (Yellow)
Reagent: Phenylhydrazine in H2SO4 + Alcohol

A

17-Hydroxycorticosteroids

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6
Q

Urinary Metabolite:

Method: Zimmerman (Red-purple)
Reagent: Meta-Dinitrobenzene

A

17-ketogenic steroids

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7
Q

Excessive production of CRH, ACTH, Glucocorticoids, Androgens

A

Hypercortisolism

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8
Q

Dexamethasone
Metyrapone

A

Supressant of Cortisol

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9
Q

Increased serum cortisol
Decreased ACTH

A

Crushing Syndrome (Adrenal)

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10
Q

Increased serum cortisol
Increased ACTH

A

Crushing disease (Pituitary)

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11
Q

High ACTH
ACTH Dependent

A

Primary ACTH (pituitary)
Ectopic ACTH
Ectopic CRF

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12
Q

Low ACTH
ACTH independent

A

Adrenal adenoma
Adrenal carcinoma
Modular Adrenal Hyperplasia
Exogenous Glucocorticoids

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13
Q

Suppressant of Cortisol:

substitute of Cortisol ; suppressing ACTH

A

Dexamethasone

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14
Q

Suppressant of Cortisol:

Blocks cortisol synthesis; block 11B- Hydroxylase = Inc. ACTH

A

Metyrapone

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15
Q

Increased serum cortisol
Decreased ACTH
Hyperglycemia

A

Cushing Syndrome

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16
Q

Excessive production of ACTH due to pituitary hormone

A

Secondary Hypercortisolism

17
Q

Hypercortisolism:

24 hr urinary Free Cortisol Test
Overnight Dexamethasone Supression Test
Midnight Salivary Cortisol Test

A

Screening Test (Hypercortisolism)

18
Q

Hypercortisolism:

Low-dose dexamethasone Test
Midnight PLASMA Cortisol Test
CRH stimulation Test

A

Confirmatory Test (Hypercortisolism)

19
Q

Supresses pituitary secretion of ACTH
Decreased ACTH stimulatio

A

Dexamethasone Suppression Test

20
Q

Provocative Testing
25X more potent than cortisol

A

Overnight/Rapid Dexamethasone Suppression Test

21
Q

Differentiate Healthy Individual from patient with Crushing Syndrome

A

Low-Dose Dexamethasone Suppression Test
(+) Elevated Cortisol

22
Q

Differentiate patients with bilateral adrenal HYPERPLASIA FROM HYPERCORTISOLISM

A

High-Dose Dexamethasone
2mg every 6hrs

CLINICAL CHEMISTRY (29 decks)

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