Endrocrine: Adrenal Cortex (Hypocortisol)

Question 1

Occurs mostly as autoimmune process

Answer 1

Primary Hypocortisolism/Primary adrenal Insufficiency/ ADDISON’s disease

Question 2

Decrease glucocorticoids and mineralocorticoids
Decreased BP, Glucose, Cortisol, Na
Increased K

Answer 2

Addison’s disease

Question 3

Hypotension
Hyperkalemia
Hypoglycemia

Answer 3

Hypocortisol

Question 4

ACTH Stimulation Test/ Consyntropin Stimulation (Primary Hypocortisolism)

Answer 4

INCREASED ACTH

DECREASED ALDOSTERONE AND CORTISOL

Question 5

Most common cause of Secondary Adrenal Insufficiency

Answer 5

Glucocorticoids Therapy

Question 6

Glucocorticoid Deficiency
Mineralocorticoid normal. NO PIGMENTATION
Normal in Cosyntropin Test; ABNORMAL Metyrapone Test

Answer 6

Secondary Hyporcortisolism

Question 7

Laboratory Test for Secondary Hypocortisolism:

Answer 7

1. ACTH Stimulation Test ( Decreased ACTH, Cortisol)
2. Metyrapone Test (alternative confirmatory)
3. Insulin Tolerance Test (Confirmatory Test)

Question 8

Development of male physical characteristics in a female; EXCESS ANDROGEN PRODUCTION–> DHEAS

Answer 8

Virilization

Question 9

Increased in 17a-hydroxyprogesterone & 11B-deoxycortisol

Answer 9

Congenital Adrenal Hyperplasia

Question 10

3B - Hydroxysteroid dehydrogenase

Answer 10

DHEA

Question 11

17a-Hydroxylase

Answer 11

Aldosterone

Question 12

11B-hydroxylase

Answer 12

11-DOC

Question 13

21B-Hydroxylase

Answer 13

17-OH- Progesterone