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CLINICAL CHEMISTRY > NPNs: Creatinine > Flashcards

NPNs: Creatinine Flashcards

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1
Q

Waste product of MUSCLE METABOLISM

A

Creatinine

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2
Q

Index for OVERALL RENAL FUNCTION

A

Creatinine

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3
Q

Evaluates the completeness of 24-hr urine collection

A

Creatinine

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4
Q

Creatinine value that shows incomplete 24-hr urine collection

A

<0.8g

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5
Q

Evaluates fetal kidney maturity

A

Creatinine

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6
Q

Creatininine RV:

Male:
Female:

A

Male: 0.9 - 1.3 (80-115 umol/L)
Female: 0.6 - 1.1 (53-97 umo/L)

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7
Q

Test that provides estimates of amount of PLASMA THAT FLOWED THROUGH KIDNEY GLOMERULI PER MINUTE

A

Creatinine Clearance

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8
Q

Creatinine is freely filtered by the glomeruli but

A

NOT REABSORBED

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9
Q

Creatining Clearance specimen

A

Plasma
24-hr Urine

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10
Q

Creatinine Clearance RV:

Male:
Female:

A

Male: 85-125 mL/min
Female: 75-112 mL/min

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11
Q

Prediction equation for patients with CKD:

A

Cockcroft-Gault Equation

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12
Q

Cockcroft-Gault Equation includes Px criteria: (4)

A

Age
Weight
Serum Creatinine
Gender

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13
Q

Uses only BLOOD CREATININE and MDRD (Modification of Diet in Renal Disease)

A

estimate Glomerular Filtration Rate

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14
Q

Creatinine Test that requires correction of gender and race

A

eGFR

eGFR includes:
Serum Creatinine
Age
BUN
Albumin
Gender
Race

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15
Q

CREATININE CHEMICAL METHODS:

Rapid, Sensitive and Specific

A

Colorimetric, Kinetic

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16
Q

CREATININE CHEMICAL METHODS:

Simple, Non-specific

A

Colorimetric, END-POINT

17
Q

CREATININE CHEMICAL METHODS:

Uses Jaffe Reaction; Color produced in Jaffe reaction

A

Direct Jaffe Reaction
Red-Orange

18
Q

CREATININE CHEMICAL METHODS:

Reagent used in Direct Jaffe Reaction

A

Alkaline Picrate (saturated picric acid and 10% NAOH)

19
Q

CREATININE CHEMICAL METHODS:

Tests under Direct Jaffe Method (2)

A
  1. Folin-Wu Method
  2. Lloyd’s and Fuller Earth method
20
Q

CREATININE CHEMICAL METHODS:

Direct Jaffe Method that is SENSITIVE BUT NOT SPECIFIC ; affected by Bilirubin and Hgb (F. dec.)

A

Folin-Wu Method

21
Q

CREATININE CHEMICAL METHODS:

Direct Jaffe Method that is SENSITIVE AND SPECIFIC but time consuming and not readily automated

A

lloyd’s and Fuller Earth

22
Q

CREATININE CHEMICAL METHODS:

Direct Jaffe Method:

Reagent used in LLoyd’s”
Reagent used in Fuler Earth’s:

A

Reagent used in LLoyd’s:
SAS - Sodium Aluminum Silicate

Reagent used in Fuller Earth’s:
AMS
Aluminum Magnesium Silicate

23
Q

CREATININE CHEMICAL METHODS:

Principle: Colorimetry-Spectrophotometry

Rate of CHANGE IN ABSORBANCE is measured between 2 points

Rapid, Inexpensive, Easy to perform

A

Kinetic Jaffe Method

24
Q

More specific than Jaffe Method
Interference: Bilirubin and Catecholamines

A

Enzymatic Method

25
Q

Creatinine Enzymatic Method:

Uses Creatininase, CK, PK, LDH
Measure: disappearance of NADH

A

Creatininase-CK Method

26
Q

Creatinine Enzymatic Method:

  • More specific than Jaffe Method
  • Not interfered by ACETOACETATE and CEPHALOSPORIN
  • Used in Dry Slide Method
A

Creatininase-Hydrogen Peroxide Method

27
Q

Creatininase-Hydrogen Peroxide Method endproduct

A

RED benzoquinoneimine dye

28
Q

Reference Method for Creatinine
Quantification of isotopically labeled compound

A

IDMS
Isotope Dilution Mass Spectrophotometry

29
Q

Better Indicator of source of elevation of either substance

A

BUN : CREATININE RATIO

30
Q

BUN : CREATININE RATIO

Reference Value:

A

10:1 - 20: 1

31
Q

Acute Tubular Necrosis
Low Protein Intake
Starvation
Vomiting
Repeated Dialysis

A

Low Ratio <10:1

32
Q

Prerenal Azotemia
High Protein Intake
Dehydration
Muscle Wasting

A

High Ratio >20:1
w/ Normal Creatinine

33
Q

Post Renal Obstruction (Nephrothiliasis)
Prostitis
Severe Infection
Acute Renal Failure

A

High Ratio >20:1
High Creatinine

34
Q

End-stage renal disease
Chronic Renal Failure

A

Normal Ratio
High BUN and Creatinine (sabay nagiincrease)

CLINICAL CHEMISTRY (29 decks)

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