Endocrine: Adrenal Medulla

Question 1

produces catecholamines

Answer 1

Adrenal Medulla

Question 2

Adrenal Medulla is composed of _____ cells

Answer 2

Chromaffin cells

Question 3

Precursor for catecholamines

Answer 3

L-Tyrosine

Question 4

Produced in the peripheral nerve tissue

Answer 4

Norepinephrine

Question 5

Little tissue storage
rapid degradation

Answer 5

Epinephrine

Question 6

Tyramine provoked release; major source using Metabolite

Answer 6

Norepinephrine

Question 7

Urine excretion <20 ug/24hr

Answer 7

Epinephrine

Question 8

Urine excretion <100 ug/24hr

Answer 8

Norepinephrine

Question 9

NOREPINEPHRINE

Heart Rate
Peripheral Vascular Resistant
Chromaffin Cell Tumor

Answer 9

Decrease - Heart Rate
Increase - Peripheral Vascular Resistant
Often - Chromaffin Cell Tumor

Question 10

EPINEPHRINE

Heart Rate
Peripheral Vascular Resistant
Chromaffin Cell Tumor

Answer 10

Increase - Heart Rate
Decrease - Peripheral Vascular Resistant
Rare - Chromaffin Cell Tumor

Question 11

EPINEPHRINE AND NOREPINEPHRINE

Arterial Blood Pressure
Skin and Renal Blood flow
Blood Glucose Level

Answer 11

Increased - Arterial Blood Pressure
Decreased - Skin and Renal Blood flow
Increased - Blood Glucose Level

Question 12

Tumor of adrenal medulla; overproduction of catecholamines

Answer 12

Pheochromocytoma

Question 13

Pheochromocytoma test:

Answer 13

1. Plasma metanephrine and normetanephrineb y HPLC
2. Clonidine supression test
3. Glucagon supression test

Question 14

Fatal malignancy in children; excess norepinephrine

Answer 14

Neuroblastoma

Question 15

Neuroblastoma

Method:

Answer 15

Urine: Pisano Method

HPLC or GMCS

Question 16

Neuroblastoma

Specimen:
Px preparation:

Answer 16

Specimen: Plasma PRECHILLED EDTA tube and 24 hrs urine

Px preparation:
Overnight fasting, No smoking, No coffee atleast 4 hrs prior; Rst for 20-30 mins

Question 16

First responders to stress, promotes fight-or-flight response

Answer 16

Catecholamines