Neural Pigments And Inclusions

Question 0

Melanin / neuromelanin

Answer 0

Blackish intracytoplasmic pigment found in substantia nigra and locus coerulus. Disappears from nigral neurons in patients who have PD.

Question 1

Lipofuscin granules

Answer 1

Pigmented cytoplasmic inclusions that commonly accumulate with aging, considered residual bodies that are derived from lysosomes

Question 2

Lewy bodies

Answer 2

Neuronal inclusions that are characteristic of Parkinson’s disease

Question 3

Negri bodies

Answer 3

Intracytoplasmic inclusions that are pathognomonic of rabies. They are found in the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum

Question 4

Hirano bodies

Answer 4

Intraneuronal, eosinophilic, rodlike inclusions that are found in the hippocampus of patients with Alzheimer’s disease

Question 5

Neurofibrillary tangles

Answer 5

Intracytoplasmic, degenerated neurofilaments. Seen in patients with Alzheimer’s disease.

Question 6

Cowdry type A inclusion bodies

Answer 6

Intranuclear inclusions that are found in nurons and glia in herpes simplex encephalitis