Heme Onc - Translocations

Question 0

8;14

Answer 0

Burkitt lymphoma
C-myc activation

Think of Burke howling to the infinite (8 on its side) on a boat (14)

Question 1

9;22

Answer 1

Philadelphia chromosome, associated with CML - BCR-abl translocation

Question 2

14;18

Answer 2

Follicular lymphoma

Think of someone FOLLING off a ship (14) to periscope (18), the 8 is the goggles, in the water.

18 - bcl-2 activation by the IgG light chain.

Question 3

15;17

Answer 3

Associated with AML, specifically the M3 subtype which responds to all-trans retinoic acid
Think of the 5 and 7 as ears on an animal(AML)

Question 4

11;14

Answer 4

Mantle cell lymphoma
Think of a boy wearing a cape playing with a toy boat, the 11 is his arms.

It is a cyclin D1 activation. If you squish D so that it is really flat and then you have a 1, it becomes 11!