Biochemistry - Grab Bag

Question 0

Cholecalciferol

Answer 0

D3, consumed in milk, formed in sun-exposed skin, in the stratum basale

I’m out in the sun so much my skin becomes coal!

Question 1

Ergocalciferol

Answer 1

D2 , ingested from plants

Aren’t ergots those dangerous things in plants that cause poisoning?

Question 2

25-OH D3

Answer 2

Storage form of vitamin D

Question 3

1,25-OH D3

Answer 3

Calcitriol, the active form of vitamin D

Question 4

Calcitriol

Answer 4

The active form of vitamin D

Question 5

Fomepizole

Answer 5

Inhibits alchohol dehydrogenase, also the antidote for methanol and ethylene glycol poisoning.

Question 6

Leflunomide

Answer 6

A DMARD

Inhibits dihydroorotate dehydrogenase

Question 7

Disulfiram

Answer 7

Inhibits acetaldehyde dehydrogenase, which causes acetaldehyde to accumulate; this contributes to hangover symptoms.

Question 8

What gets produced during ethanol metabolism?

Answer 8

Acetate and two NADH

The NADH/NAD+ ratio disfavors TCA production of NADH and leads to increased utilization of acetyl-coa for ketogenesis leading to ketoacidosis and lipogenesis - hepatosteatosis.