Neoplasia classification

Question 1

Early transformation

Answer 1

Often look normal but increased proliferation, not hyperplasia because genetically abnormal

Question 2

Features of transformed cells

Answer 2

-anaplasia
-Pleomorphism

Question 3

What should classification of neoplasia include

Answer 3

-Cell origin
-Morphological features
-Anticipated biological behavior

Question 4

Cell origin

Answer 4

Epithelial or mesenchymal. Most neoplasms are from only one cell type

Question 5

Epithelial neoplasma

Answer 5

-Glandular (hepatocytes, mammary epithelium, skin adnexa)
-Mucosa
-Epidermis
-Germinal epithelium

Question 6

Adeno

Answer 6

Glandular (looks glandular)

Question 7

Papillo

Answer 7

Papillary (finger like projections)

Question 8

Epithelial neoplasm morphology

Answer 8

-Usually round
-Can be diffuse sheets
-Glandular or tubular
-Pappillary

Question 9

Epithelial neoplasm examples

Answer 9

Squamous cell carcinoma
-Mammary adenocarcinoma
-Thyroid adenoma
-Sebaceous adenoma
-Cholangio bile duct carcinoma

Question 10

Mesenchymal neoplasm morphology

Answer 10

-Arise from CT, endothelium, muscle, hematopoetic or lymphoid cells
-Usually spindle shaped except hematopoetic and lymphoid cells
-Arranged in whorls, interlacing bundles, diffuse shapes

Question 11

Rhabdo

Answer 11

Muscle

Question 12

Lymphosarcoma morphology

Answer 12

Round not spindles

Question 13

Examples of mesenchymal neoplasms

Answer 13

-Fibrosarcoma
-Osteosarcoma
-Leiomyosarcoma
-Hemangiosarcoma

Question 14

Examples of mixed cell neoplasia

Answer 14

-Fibropapilloma
-Equine sarcoid
-Mixed mammary tumor
-Teratoma

Question 15

Classifying neoplasms based off of biological behavior

Answer 15

Classified as benign or malignant which is determined by primarily morphological features

Question 16

Benign neoplasms

Answer 16

-More favorable prognosis
-Suffix -oma

Question 17

Benign morphology

Answer 17

-Well differentiated appearance similar to normal cell and tissue
-Well delineated distinct boundary, some encapsulated

Question 18

Benign behavior

Answer 18

-Slow growing
-Localized and non invasive
-Sometimes retain some functions of normal cell and tissue derived from

Question 19

Malignant neoplasms

Answer 19

-Unfavorable prognosis
-carcinoma for epithelial neoplasm
-Sarcoma for mesenchymal neoplasm

Question 20

Malignant morphology

Answer 20

-Poorly differentiated
-anaplasia
-Lot of pleomorphisms
-Hyperchromatic nuclei due to increased DNA
-Poorly delineated

Question 21

Malignant behavior

Answer 21

-Rapidly growing
-Infiltrative and invasive
-Metastasis spread to secondary site distinct from primary site
-Not all metastasize

Question 22

Neoplasms that don’t follow neoplasm classification criteria

Answer 22

-Histiocytoma: benign looks malignant
-Lymphosarcoma: malignant looks benign