Autoimmunity

Question 1

What are some mechanisms in which we get autoimmunity

Answer 1

-Sequestered antigens
-Alteration of self-antigens (viral or chemical alteration)
-Alteration of immune reactivity (loss of tolerance to self-antigens

Question 2

Pemphigus foliaceus

Answer 2

Most common immune skin disease of SA.
Subcorneal vesicular to pustular dermatitis
Antibodies to desmoglein 1(can be natural or drug induced)

Question 3

CID

Answer 3

Combined immunodeficiency
Inherited defects involve multiple immune cells
Functional B and T cells absent or decreased
Die before 6mo due to disease

Question 4

Selective immunodeficiency examples

Answer 4

IgM deficiency in Arabs and Dobermans
IgG deficiency in dogs and cattle
T cell trait A-46 in Friesian cattle

Question 5

Canine parvovirus type 2

Answer 5

Attacks rapidly dividing cells (bone marrow, enterocytes, lymphoid tissue, cardiac myocytes) Radiomimetic
Lesions include crypt enterocyte necrosis, lymphoid necrosis and myocarditis