Muscle Tissue Flashcards
epimysium
dense irregular CT that separates muscle from surrounding tissue and organs and is connected to deep fascia
perimysium
divides muscle into series of internal compartments (fasicles)
endomysium
surrounds each skeletal muscle fiber; binds each muscle to its neighbor. satellite cells lie between endomysium
organization of skeletal muscle
skeletal muscle, fascicle, muscle fiber, myofibril, myofilaments
muscle fibers
- called fibers because they’re long, run from origin to insertion, parallel to one another
- contains muscle cell/fiber contains myofibrils
muscle fascicles
contain muscle cells/fibers, within the fascicle, all muscle fibers are parallel to one another, surrounding each muscle cell/fiber in the fascicle is endomysium made of reticular fibers
myofibrils
-contain the thick (myosin) and thin filaments arranged into sarcomeres
sarcomeres
Z-disc to Z-dic, parallel to each other and to the long axis of the muscle (origin to insertion)
thin filaments
- attach to the Z-discs at the ends of the sarcomere
- composed of actin, troponin, and tropomyosin
troponin
binds to calcium, myosin can then bind to actin (forms a cross-bridge)
thick filaments
center of the sarcomere, composed of protein myosin, myosin head is what attaches to actin in the presence of calcium
anatomy of a sarcomere
A band: entire length of thick filaments, stains darker
I band: region that only includes thin filaments, stains lighter
sarcoplasmic reticulum
- storehouse for calcium, when a muscle cells has an electric signal this calcium is released
- increase in calcium is the sarcoplasm binds to troponin and allows for formation of cross-bridges
sliding filament mechanism
- myosin binds to actin creating a cross-bridge between the two filaments
- myosin head rotates towards the center of the sarcomere (power stroke) the power stroke pulls the thin filaments towards the center of the sarcomere
- sarcomeres shorten (Z-discs move closer) and both the H-zone (only thick filaments) and the I-band decrease in size
neural innervation
-somatic motor neurons release acetylcholine (ACH) onto muscle fibers
acetylcholine
causes muscle cell to generate an electric signal (action potential) which causes the cell to release calcium and contract by the sliding filament mechanism
neuromuscular junction
ACH released by the somatic motor neuron binds nicotinic receptors on the sarcolemma
action potential
in response to ACH-nicotinic receptor binding leads to calcium release from the SR
calcium release from SR
this calcium binds to troponin and allows for cross-bridges to form and the sliding filament mechanism to occur
difference between muscle fiber types
vary in content of myoglobin, the speed at which they undergo the sliding filament mechanism, and how they produce ATP
skeletal muscle fiber types
- slow oxidative fibers (type I)
- fast oxidative-glycolytic (type IIa)
- fast glycolytic (type IIb)
muscular dystrophy
the protein dystrophin connects thin filaments of the sarcomere to the membrane and is thought to transmit tension generated by muscle contraction to the tendon
muscle origin
proximal and they are stationary during muscle contraction
insertion
distal and they move during contraction