MSK path XII Flashcards
skeltal mm neoplasms
bengn or malignant
almost always malignant
subtypes of rhabdomyosarcoma
alveolar, embryonal and pleomorphic
msot common soft tissue sarcoma of childhood and adolescence
rhabdomyosarcoma
what rhabdo is seen in adults
pleomorphic
presentation of childhood rhabdos
sinuses, head and neck and GU tract
sarcoma botryoides
rhabdo in vagina
looks like cluster of grapes
visible cross striations and sheets of primitive round and spindled cell sin myxoid stroma
rhabdo
Tx rhabdos
surgery an chemo +/- radiation
which rhabdo has best prognosis
boytroid embryonal
msot common benign tumor in women
leiomyomas
bleeding out of pyloric sphincter, looks like volcano
GIST tumor
ckit +
pilar leiomyomas
leiomyomas that arise in skin, nipples, scrotum and labia
sometimes muscularis of gut
where do leiomyosarcomas arise
deep soft tissues of extremities and retroperitoneum
painless firm mass in retroperitoneum
eosinophilic spindle cells with blunt ended hyperchromatic nuclei arranged in interweaving fascicles
leiomyosarcomas
ab staining for leiomyosarcomas
Ab to smooth mm actin and desmin
where does leiomyosarcoma mets to
lungs
Carcinoma with biphasic area suggesting sarcoma
aspirate in knee
synovial sarcoma
presentation synovial sarcomas
20s 40s
deep seated mass that has been present for several years
what are epithelial markers for synovial sarcoma
keratins
Tx synovial sarcoma
surgery and chemo
mets of synovial sarcoma
lungs and regional lymph nodes
what is new name for malignant fibrous histiocytoma
pleomorphic sarcoma
fascicles of spindle cells in a storiform pattern (pinwheel)
pleomorphic sarcoma
herringbone pattern
fibrosarcoma
largest category of adult sarcomas
undifferentiated pleomorphic sarcoma
where do most pleomorphic sarcomas arise
in the deep soft tissues of extremity
coagulative necrosis is seen in what tumors
fibrosarcomas- pleomporphic
