Derm path IV

Question 1

25 year old with alot of itching and rash that came on suddenly

Answer 1

mast cell dependent and IgE dependent

acute allergic reaction

Question 2

what type of hives is mast cell dependent and IgE independent

Answer 2

drug or other substance that triggers mast cells directly

Question 3

What type of hives is Mast Cell dependent IgE dependent

Answer 3

acute allergic reaction

Question 4

what type of hives is mast cell independent and IgE independent

Answer 4

aspirin induced vasodilation

hereditary angioneurotic edema (C1 inhibitor deficiency)

Question 5

Tx for acute urticaria

Answer 5

antihistamines, subcut epinephrine, IM injections corticosteroids

Question 6

patient with known c1 inhibitor deficiency has acute urticaria, what do you Tx with

Answer 6

C1 inhibitor concentrates, kallikrein inhibitor or fresh frozen plasma

Question 7

what does the rash look like in acute urticaria

Answer 7

wheals that are erythematous edematous circular plaques covered by intact normal epidermal surface
commonly on trunk and extremities

Question 8

blanching means what

Answer 8

erythema fades to white with direct contact– good.. most likely just urticaria

Question 9

how long does acute urticaria last

Answer 9

24 hours

sometimes days- months

Question 10

what is spongiotic dermatitis

Answer 10

eczema

Question 11

epidermal edema with prominent lymphocytes in dermis and epidermis

Answer 11

eczema

Question 12

clinical sign eczema

Answer 12

acute onset red papulovesicular lesions which may ooze or crust

Question 13

what type of HS is eczema

Answer 13

T cell mediated type IV

Question 14

what is erythema multiforme

Answer 14

HS reaction to drugs, infections, malignancy, collagen vascular disorderts

Question 15

what type of infections can cause erythema multiform

Answer 15

Herpes
deep fungal (histo)
salmonella typhii
leprosy

Question 16

what drugs can cause erythema multiforme

Answer 16

antibiotics
salicylates
anti malerials

Question 17

what is the multiforme pattern

Answer 17

red pale red

Question 18

what is the severe systemic fibrile form of erythema multiforme with mucosal involvement

Answer 18

stevens johnson syndrome

Question 19

what is toxic epidermal necrolysis

Answer 19

form of erythema multiforme with diffuse necrosis and sloughing of skin and mucosae

Question 20

what is seborrheic dermatitis

Answer 20

chronic dermatitis

Question 21

where is seborrheic dermatitis found

Answer 21

scalp forehead and glabella space (upper eybrow)

high density sebaceous glands

Question 22

what infection can cause seborrheic dermatitis

Answer 22

malassezia furfur

Question 23

what is psoriasis

Answer 23

chronic skin condition

affects skin of elbows, knees, scalp, lumbosacral area, intergluteal cleft and glans penis

Question 24

psoriasis is assoc with

Answer 24

arthritis

Question 25

HLA psoriasis

Answer 25

cW 0602 | increased CD4 TH1 sensitized cells set off other T cells causing increased cytokines leading to epidermal proliferation

Question 26

typical lesions in psoriasis

Answer 26

well demarcated pink-salmon plaque

Question 27

koebner phenomenon

Answer 27

trauma can induce psoriatic lesions in predisposed people

Question 28

what causes lichen simplex chornicus

Answer 28

chronic rubbing or scratchin

Question 29

nodular lichen simplex chronicus

Answer 29

prurigo nodularis

Question 30

lichen planus

Answer 30

self limiting chornic inflammatory condition of skin and mucous membranes

Question 31

prognosis lichen planus

Answer 31

resolves spontaneously 1-2 years after onset

Question 32

clincal presentation lichen planus

Answer 32

multiple plaques symmetrically distributed on extremities and glans penis wickham striae appearance

Question 33

sawtoothing and civatte bodies

Answer 33

lichen planus

Question 34

what is discoid lupus erythematous

Answer 34

localized cutaneous manifestations of SLE with no assoc systemic manifestations

Question 35

major cutaneous findings in discoid lupus erythematosus

Answer 35

malar erythema | discoid (coin like) scaling plaques

Question 36

chronic plaques with thinned atrophic epidermis and areas of dilated tortuous dermal vessels

Answer 36

lupus erythematosus

Question 37

central hypopigmentation surrounded by peripheral hyperpigmentation

Answer 37

lupus erythematosus

Question 38

lymphopcytes in superficial and deep dermis | thinned epidermis with loss of rete ridges and hyperkeratosis

Answer 38

lupus errythematosus

Question 39

granular deposits of IgG and C3 at dermoepidermal junction

Answer 39

+"band test" | lupus erythematosus

Question 40

population commonly affected by rosacea

Answer 40

30-60 y.o F

Question 41

stages of rosacea

Answer 41

- pre-rosacea (flushing) - erythematotelengiectatic - papulopustular - phymatous

Question 42

what skin condition has perifollicular inflammation changes similar to acne vulgaris

Answer 42

rosacea

Question 43

what is a common friction lbister

Answer 43

intraepidermal blister usually just beneath stratum granulosum with scant or no inflammation in papillary dermis

Question 44

what are the immune mediated bulla

Answer 44

pemphigus group of diseases bullous pemphigoid dermatitis herpetiformis

Question 45

what are the genetic blistering diseases

Answer 45

epidermolysis bullosa- -inherited defects in collagen, laminin leading to several disorders with weak skin and blistering -porphyrias

Question 46

separation at the dermal epidermal junction is what type of blister

Answer 46

subepidermal

Question 47

in general what are the pemphigus group of diseases

Answer 47

autoimmune skin diseases: IgG autoAb to desmosomes (spinous processes) of squamous epithelial cells

Question 48

what are the 4 clinical and pathologic types of pemphigus diseases

Answer 48

``` pemphigus vulgaris pemphigus vegetans pemphigus foliaceus pemphibus erythematosis -paraneoplastic pemphigus ```

Question 49

what is most common pemphigus disease

Answer 49

pemphigus vulgaris, invovles mucosa and scalp, face, axilla, groin and other pressure points

Question 50

what is pemphigus foliaceus

Answer 50

benign course, involves face, scalp, chest and back, spares mucous membranes epidemic in south america

Question 51

when do you see paraneoplastic pemphigus

Answer 51

with malignancies (lymphoma)