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Year2 MSK exam 1 > Derm path IV > Flashcards

Derm path IV Flashcards

1
Q

25 year old with alot of itching and rash that came on suddenly

A

mast cell dependent and IgE dependent

acute allergic reaction

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2
Q

what type of hives is mast cell dependent and IgE independent

A

drug or other substance that triggers mast cells directly

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3
Q

What type of hives is Mast Cell dependent IgE dependent

A

acute allergic reaction

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4
Q

what type of hives is mast cell independent and IgE independent

A

aspirin induced vasodilation

hereditary angioneurotic edema (C1 inhibitor deficiency)

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5
Q

Tx for acute urticaria

A

antihistamines, subcut epinephrine, IM injections corticosteroids

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6
Q

patient with known c1 inhibitor deficiency has acute urticaria, what do you Tx with

A

C1 inhibitor concentrates, kallikrein inhibitor or fresh frozen plasma

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7
Q

what does the rash look like in acute urticaria

A

wheals that are erythematous edematous circular plaques covered by intact normal epidermal surface
commonly on trunk and extremities

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8
Q

blanching means what

A

erythema fades to white with direct contact– good.. most likely just urticaria

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9
Q

how long does acute urticaria last

A

24 hours

sometimes days- months

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10
Q

what is spongiotic dermatitis

A

eczema

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11
Q

epidermal edema with prominent lymphocytes in dermis and epidermis

A

eczema

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12
Q

clinical sign eczema

A

acute onset red papulovesicular lesions which may ooze or crust

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13
Q

what type of HS is eczema

A

T cell mediated type IV

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14
Q

what is erythema multiforme

A

HS reaction to drugs, infections, malignancy, collagen vascular disorderts

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15
Q

what type of infections can cause erythema multiform

A

Herpes
deep fungal (histo)
salmonella typhii
leprosy

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16
Q

what drugs can cause erythema multiforme

A

antibiotics
salicylates
anti malerials

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17
Q

what is the multiforme pattern

A

red pale red

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18
Q

what is the severe systemic fibrile form of erythema multiforme with mucosal involvement

A

stevens johnson syndrome

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19
Q

what is toxic epidermal necrolysis

A

form of erythema multiforme with diffuse necrosis and sloughing of skin and mucosae

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20
Q

what is seborrheic dermatitis

A

chronic dermatitis

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21
Q

where is seborrheic dermatitis found

A

scalp forehead and glabella space (upper eybrow)

high density sebaceous glands

22
Q

what infection can cause seborrheic dermatitis

A

malassezia furfur

23
Q

what is psoriasis

A

chronic skin condition

affects skin of elbows, knees, scalp, lumbosacral area, intergluteal cleft and glans penis

24
Q

psoriasis is assoc with

A

arthritis

25
Q

HLA psoriasis

A

cW 0602

increased CD4 TH1 sensitized cells set off other T cells causing increased cytokines leading to epidermal proliferation

26
Q

typical lesions in psoriasis

A

well demarcated pink-salmon plaque

27
Q

koebner phenomenon

A

trauma can induce psoriatic lesions in predisposed people

28
Q

what causes lichen simplex chornicus

A

chronic rubbing or scratchin

29
Q

nodular lichen simplex chronicus

A

prurigo nodularis

30
Q

lichen planus

A

self limiting chornic inflammatory condition of skin and mucous membranes

31
Q

prognosis lichen planus

A

resolves spontaneously 1-2 years after onset

32
Q

clincal presentation lichen planus

A

multiple plaques symmetrically distributed on extremities and glans penis
wickham striae appearance

33
Q

sawtoothing and civatte bodies

A

lichen planus

34
Q

what is discoid lupus erythematous

A

localized cutaneous manifestations of SLE with no assoc systemic manifestations

35
Q

major cutaneous findings in discoid lupus erythematosus

A

malar erythema

discoid (coin like) scaling plaques

36
Q

chronic plaques with thinned atrophic epidermis and areas of dilated tortuous dermal vessels

A

lupus erythematosus

37
Q

central hypopigmentation surrounded by peripheral hyperpigmentation

A

lupus erythematosus

38
Q

lymphopcytes in superficial and deep dermis

thinned epidermis with loss of rete ridges and hyperkeratosis

A

lupus errythematosus

39
Q

granular deposits of IgG and C3 at dermoepidermal junction

A

+“band test”

lupus erythematosus

40
Q

population commonly affected by rosacea

A

30-60 y.o F

41
Q

stages of rosacea

A
  • pre-rosacea (flushing)
  • erythematotelengiectatic
  • papulopustular
  • phymatous
42
Q

what skin condition has perifollicular inflammation changes similar to acne vulgaris

A

rosacea

43
Q

what is a common friction lbister

A

intraepidermal blister usually just beneath stratum granulosum with scant or no inflammation in papillary dermis

44
Q

what are the immune mediated bulla

A

pemphigus group of diseases
bullous pemphigoid
dermatitis herpetiformis

45
Q

what are the genetic blistering diseases

A

epidermolysis bullosa- -inherited defects in collagen, laminin leading to several disorders with weak skin and blistering
-porphyrias

46
Q

separation at the dermal epidermal junction is what type of blister

A

subepidermal

47
Q

in general what are the pemphigus group of diseases

A

autoimmune skin diseases: IgG autoAb to desmosomes (spinous processes) of squamous epithelial cells

48
Q

what are the 4 clinical and pathologic types of pemphigus diseases

A 
pemphigus vulgaris
pemphigus vegetans
pemphigus foliaceus
pemphibus erythematosis
-paraneoplastic pemphigus
49
Q

what is most common pemphigus disease

A

pemphigus vulgaris, invovles mucosa and scalp, face, axilla, groin and other pressure points

50
Q

what is pemphigus foliaceus

A

benign course, involves face, scalp, chest and back, spares mucous membranes
epidemic in south america

51
Q

when do you see paraneoplastic pemphigus

A

with malignancies (lymphoma)

Year2 MSK exam 1 (26 decks)

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