Derm path V

Question 1

what are the autoAb in pemphigus vulgaris and cause what type of blisters

Answer 1

Dsg1 Dsg3 desmosomes

cause suprabasal epidermis blisters

Question 2

what are the autoAb in pemphigus foliaceus

Answer 2

Dsg1 causing subcorneal blisters

Question 3

autoAb in bullous phemphigoid

Answer 3

bind BPAG2, component of hemidesmosomes leading to blisters at lamina lucida of BM

Question 4

where does bullous pemphigoid occur

Answer 4

inner aspects of thighs, flexor surfaces of arms and axilla( areas prone to rubbing)

Question 5

what type of blisters are bullous pemphigoid

Answer 5

subepidermal

Question 6

dermatitis herpetiformois

Answer 6

IgA to gliadin attacks reticulin in dermal papillae fibrils

Question 7

assocations with dermatitis herpetiformis

Answer 7

celiac disease, sprue,

anti gliadin Ab cross react with reticulin in anchoring fibrils

Question 8

clincal presentation of dermatitis herpetiformis

Answer 8

pruritic plaques and vesicles on extensor surfaces, elbows, knees, upper back and buttocks

Question 9

what is panniculitis

Answer 9

inflammation of subcut fatty tissue

septal and lobular

Question 10

erythema nodosum

Answer 10

acute septal inflammation assoc with infection by many agents

Question 11

what can cause erythema nodosum

Answer 11

beta strep
TB
sarcoidosis
IBD
malignancies
sulfonamides
oral contraceptiv es

Question 12

what can cause erythema induratum

Answer 12

uncommon lobular panniculitis of unknown etiology

Question 13

what is weber christian disease

Answer 13

relapsing febrile nodular panniculitis in children and adults

Question 14

what is factitial panniculitis

Answer 14

self induced lobular from traumatic injury and infections

Question 15

what type of panniculitis can present in lupus

Answer 15

lobular

Question 16

what causes verruca vulgaris

Answer 16

HPV
cutaneous 2 and 4
anogenital 6 and 11

Question 17

what do the warts in verruca vulgaris look like

Answer 17

gray-white papules

cobble stone and firm to palpation

Question 18

condyloma plantaris

Answer 18

verruca vulgaris on soles of feet and palms on hand

Question 19

condyloma acuminatum

Answer 19

anogenital with cauliflower appearance

Question 20

keratohyaline granules in epithlial hyperplasia

Answer 20

verruca vulgaris

Question 21

what causes molluscum contagiosum

Answer 21

pox virus

Question 22

clinical presentation molluscum contagiosum

Answer 22

.2-.4 cm nodules on face, trunk and anogenital area

spread by direct contact

Question 23

ellipsoid cytoplasmic inclusions

Answer 23

molluscum bodies

Question 24

what is acne vulgaris

Answer 24

chronic infection of hair follicle by lipase producing propionibacterium acnes

Question 25

Tx for P acnes | or acne vulgaris

Answer 25

retin A with antibiotics like minocycline

Question 26

causes of impetigo

Answer 26

staph and strep

Question 27

types of impetifo

Answer 27

bullosa and contagiosa

Question 28

how does staph cause impetigo

Answer 28

toxins cleave desmoglein 1 localized to stratum corneum honey colored crust

Question 29

Tx impetigo

Answer 29

anti bacterial soap and topical antibiotic

Question 30

what causes superficial fungal infections

Answer 30

dermatophyte

Question 31

superficial fungi cause infection where

Answer 31

confined to stratum corneum of epidermis | thrive in keratin layer

Question 32

what are predisposing conditions for supergiical fungi

Answer 32

high moisture content lack exposure to sunlight increased temp of skin

Question 33

onychomycosis

Answer 33

fungal infection in nail beds

Question 34

tinea versicolor

Answer 34

malassezia furfur | yeast infection causes it

Question 35

what are arthropods

Answer 35

spiders ticks chiggers lice and scabies

Question 36

what are considered insecta

Answer 36

``` bedbugs wasps bees flies mosquitoes ```

Question 37

what bugs cause direct injurious effect

Answer 37

mosquitoes and chiggers

Question 38

what bugs cause acute or delayed HS reaction

Answer 38

bee or wasp

Question 39

what bugs cause direct toxin effect

Answer 39

brown recluse spider

Question 40

what bugs are vectors for what diseases

Answer 40

mosquitoes: malaria, west nile virus, dengue ticks: lyme disease, RMSF

Question 41

what is ichthyosis

Answer 41

genetic abnormality leading to hyperkeratosis

Question 42

what is epidermolysis bullosa

Answer 42

genetic abnormalities in structural proteins leading to massive bullae

Question 43

porphyrias

Answer 43

auto dominant defects in heme synthesis causes urticaria and subepidermal vesicles when exposed to sun

Question 44

simplex type epidermolysis bullosa

Answer 44

keratin 14 5 mutation leads to suprabasalar lesion

Question 45

what porphyrias cause acute neurovisceral with GI and neural Sx

Answer 45

acute intermittent | aminolevulnic acid dehydratase deficient

Question 46

what porphyrias cause acute neurovisceral with curatnous problems

Answer 46

variegate and hereditary coproporphyria

Question 47

what porphyrias cause non acute (cutaneous with light induced lesions)

Answer 47

congenital erythropoetic erythropoeitic x linked protoporphyria cutanea tarda-- assoc with hypertrichosis urine can be red or dark with light exposure