Derm path V Flashcards
what are the autoAb in pemphigus vulgaris and cause what type of blisters
Dsg1 Dsg3 desmosomes
cause suprabasal epidermis blisters
what are the autoAb in pemphigus foliaceus
Dsg1 causing subcorneal blisters
autoAb in bullous phemphigoid
bind BPAG2, component of hemidesmosomes leading to blisters at lamina lucida of BM
where does bullous pemphigoid occur
inner aspects of thighs, flexor surfaces of arms and axilla( areas prone to rubbing)
what type of blisters are bullous pemphigoid
subepidermal
dermatitis herpetiformois
IgA to gliadin attacks reticulin in dermal papillae fibrils
assocations with dermatitis herpetiformis
celiac disease, sprue,
anti gliadin Ab cross react with reticulin in anchoring fibrils
clincal presentation of dermatitis herpetiformis
pruritic plaques and vesicles on extensor surfaces, elbows, knees, upper back and buttocks
what is panniculitis
inflammation of subcut fatty tissue
septal and lobular
erythema nodosum
acute septal inflammation assoc with infection by many agents
what can cause erythema nodosum
beta strep TB sarcoidosis IBD malignancies sulfonamides oral contraceptiv es
what can cause erythema induratum
uncommon lobular panniculitis of unknown etiology
what is weber christian disease
relapsing febrile nodular panniculitis in children and adults
what is factitial panniculitis
self induced lobular from traumatic injury and infections
what type of panniculitis can present in lupus
lobular
what causes verruca vulgaris
HPV
cutaneous 2 and 4
anogenital 6 and 11
what do the warts in verruca vulgaris look like
gray-white papules
cobble stone and firm to palpation
condyloma plantaris
verruca vulgaris on soles of feet and palms on hand
condyloma acuminatum
anogenital with cauliflower appearance
keratohyaline granules in epithlial hyperplasia
verruca vulgaris
what causes molluscum contagiosum
pox virus
clinical presentation molluscum contagiosum
.2-.4 cm nodules on face, trunk and anogenital area
spread by direct contact
ellipsoid cytoplasmic inclusions
molluscum bodies
what is acne vulgaris
chronic infection of hair follicle by lipase producing propionibacterium acnes
Tx for P acnes
or acne vulgaris
retin A with antibiotics like minocycline
causes of impetigo
staph and strep
types of impetifo
bullosa and contagiosa
how does staph cause impetigo
toxins cleave desmoglein 1
localized to stratum corneum
honey colored crust
Tx impetigo
anti bacterial soap and topical antibiotic
what causes superficial fungal infections
dermatophyte
superficial fungi cause infection where
confined to stratum corneum of epidermis
thrive in keratin layer
what are predisposing conditions for supergiical fungi
high moisture content
lack exposure to sunlight
increased temp of skin
onychomycosis
fungal infection in nail beds
tinea versicolor
malassezia furfur
yeast infection causes it
what are arthropods
spiders ticks chiggers lice and scabies
what are considered insecta
bedbugs wasps bees flies mosquitoes
what bugs cause direct injurious effect
mosquitoes and chiggers
what bugs cause acute or delayed HS reaction
bee or wasp
what bugs cause direct toxin effect
brown recluse spider
what bugs are vectors for what diseases
mosquitoes: malaria, west nile virus, dengue
ticks: lyme disease, RMSF
what is ichthyosis
genetic abnormality leading to hyperkeratosis
what is epidermolysis bullosa
genetic abnormalities in structural proteins leading to massive bullae
porphyrias
auto dominant
defects in heme synthesis
causes urticaria and subepidermal vesicles when exposed to sun
simplex type epidermolysis bullosa
keratin 14 5 mutation leads to suprabasalar lesion
what porphyrias cause acute neurovisceral with GI and neural Sx
acute intermittent
aminolevulnic acid dehydratase deficient
what porphyrias cause acute neurovisceral with curatnous problems
variegate and hereditary coproporphyria
what porphyrias cause non acute (cutaneous with light induced lesions)
congenital erythropoetic
erythropoeitic
x linked protoporphyria
cutanea tarda– assoc with hypertrichosis
urine can be red or dark with light exposure
