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Year2 MSK exam 1 > Derm path V > Flashcards

Derm path V Flashcards

1
Q

what are the autoAb in pemphigus vulgaris and cause what type of blisters

A

Dsg1 Dsg3 desmosomes

cause suprabasal epidermis blisters

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2
Q

what are the autoAb in pemphigus foliaceus

A

Dsg1 causing subcorneal blisters

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3
Q

autoAb in bullous phemphigoid

A

bind BPAG2, component of hemidesmosomes leading to blisters at lamina lucida of BM

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4
Q

where does bullous pemphigoid occur

A

inner aspects of thighs, flexor surfaces of arms and axilla( areas prone to rubbing)

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5
Q

what type of blisters are bullous pemphigoid

A

subepidermal

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6
Q

dermatitis herpetiformois

A

IgA to gliadin attacks reticulin in dermal papillae fibrils

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7
Q

assocations with dermatitis herpetiformis

A

celiac disease, sprue,

anti gliadin Ab cross react with reticulin in anchoring fibrils

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8
Q

clincal presentation of dermatitis herpetiformis

A

pruritic plaques and vesicles on extensor surfaces, elbows, knees, upper back and buttocks

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9
Q

what is panniculitis

A

inflammation of subcut fatty tissue

septal and lobular

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10
Q

erythema nodosum

A

acute septal inflammation assoc with infection by many agents

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11
Q

what can cause erythema nodosum

A 
beta strep
TB
sarcoidosis
IBD
malignancies
sulfonamides
oral contraceptiv es
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12
Q

what can cause erythema induratum

A

uncommon lobular panniculitis of unknown etiology

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13
Q

what is weber christian disease

A

relapsing febrile nodular panniculitis in children and adults

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14
Q

what is factitial panniculitis

A

self induced lobular from traumatic injury and infections

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15
Q

what type of panniculitis can present in lupus

A

lobular

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16
Q

what causes verruca vulgaris

A

HPV
cutaneous 2 and 4
anogenital 6 and 11

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17
Q

what do the warts in verruca vulgaris look like

A

gray-white papules

cobble stone and firm to palpation

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18
Q

condyloma plantaris

A

verruca vulgaris on soles of feet and palms on hand

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19
Q

condyloma acuminatum

A

anogenital with cauliflower appearance

20
Q

keratohyaline granules in epithlial hyperplasia

A

verruca vulgaris

21
Q

what causes molluscum contagiosum

A

pox virus

22
Q

clinical presentation molluscum contagiosum

A

.2-.4 cm nodules on face, trunk and anogenital area

spread by direct contact

23
Q

ellipsoid cytoplasmic inclusions

A

molluscum bodies

24
Q

what is acne vulgaris

A

chronic infection of hair follicle by lipase producing propionibacterium acnes

25
Q

Tx for P acnes

or acne vulgaris

A

retin A with antibiotics like minocycline

26
Q

causes of impetigo

A

staph and strep

27
Q

types of impetifo

A

bullosa and contagiosa

28
Q

how does staph cause impetigo

A

toxins cleave desmoglein 1
localized to stratum corneum
honey colored crust

29
Q

Tx impetigo

A

anti bacterial soap and topical antibiotic

30
Q

what causes superficial fungal infections

A

dermatophyte

31
Q

superficial fungi cause infection where

A

confined to stratum corneum of epidermis

thrive in keratin layer

32
Q

what are predisposing conditions for supergiical fungi

A

high moisture content
lack exposure to sunlight
increased temp of skin

33
Q

onychomycosis

A

fungal infection in nail beds

34
Q

tinea versicolor

A

malassezia furfur

yeast infection causes it

35
Q

what are arthropods

A

spiders ticks chiggers lice and scabies

36
Q

what are considered insecta

A 
bedbugs
wasps
bees
flies
mosquitoes
37
Q

what bugs cause direct injurious effect

A

mosquitoes and chiggers

38
Q

what bugs cause acute or delayed HS reaction

A

bee or wasp

39
Q

what bugs cause direct toxin effect

A

brown recluse spider

40
Q

what bugs are vectors for what diseases

A

mosquitoes: malaria, west nile virus, dengue
ticks: lyme disease, RMSF

41
Q

what is ichthyosis

A

genetic abnormality leading to hyperkeratosis

42
Q

what is epidermolysis bullosa

A

genetic abnormalities in structural proteins leading to massive bullae

43
Q

porphyrias

A

auto dominant
defects in heme synthesis
causes urticaria and subepidermal vesicles when exposed to sun

44
Q

simplex type epidermolysis bullosa

A

keratin 14 5 mutation leads to suprabasalar lesion

45
Q

what porphyrias cause acute neurovisceral with GI and neural Sx

A

acute intermittent

aminolevulnic acid dehydratase deficient

46
Q

what porphyrias cause acute neurovisceral with curatnous problems

A

variegate and hereditary coproporphyria

47
Q

what porphyrias cause non acute (cutaneous with light induced lesions)

A

congenital erythropoetic
erythropoeitic
x linked protoporphyria
cutanea tarda– assoc with hypertrichosis
urine can be red or dark with light exposure

Year2 MSK exam 1 (26 decks)

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