MSK path XI

Question 1

ganglions synovial cysts and osteochondral loose bodies form from what

Answer 1

trauma or degenerative processes

Question 2

what is a ganglion

Answer 2

1-1.5 cm cyst usually near joint capsule or tendon sheath

usually around wrist

Question 3

what causes ganglion cyst

Answer 3

cystic or myxoid degeneration of CT

lacks cell lining

Question 4

do ganglion cysts communicate with joint space

Answer 4

no

Question 5

what can cause synovial cyst

Answer 5

herniation of synovium though joint capsule or massive enlargement of bursa

Question 6

what is a baker cyst

Answer 6

synovial cyst in popliteal space in RA

Question 7

synovial lining in synovial vyst

Answer 7

hyperplastic and contain inflammatory cells and fibrin

Question 8

what do ganglion and synovial cysts feel like

Answer 8

soft squishy

Question 9

what is a tenosynovial giant cell tumor

Answer 9

closely related benign neoplasms that develop in synovial lining of joints, tendon sheaths and bursae

Question 10

clinical variants tenosynovial giant cell tumors

Answer 10

diffuse type- pigmented villonodular synovitis)

localized type- giant cell tumor of tendon sheath

Question 11

diffuse tenosynovial giant cell tumors form where

Answer 11

large joints

Question 12

localized type tenosynovial giant cell form where

Answer 12

discrete nodule attached to tendon sheat (commonly the hand)

Question 13

Dx age for tenosynovial giant cell tumors

Answer 13

20-40s

Question 14

color diffuse tenosynovial giant cell tumors

Answer 14

red brown, orange yellow
red brown stripes or folds “tiger stripe”
infiltrate subsynovial tissue

Question 15

localized type tenosynovial giant cell shape

Answer 15

well circumscribed

Question 16

diffuse type tenosynovial giant cell type presents where

Answer 16

knee then hip, ankle, and calcaneocuboid joints

Question 17

Sx diffuse type tenosynovial giant cell

Answer 17

pain, locking and recurrent swelling similar to monoarticular arthritis

Question 18

what limits ROM in joint in tenosynovial giant cell tumors

Answer 18

tumor progression

Question 19

characteristics of localized type tenosynovial giant cell tumor

Answer 19

solitary, slow growing, painless

usually tendon sheaths on wrists and fingers

Question 20

most common mesenchymal neoplasm of hand

Answer 20

localized type tenosynovial giant cell

Question 21

tenosynovial giant cell tumors are Tx how

Answer 21

surgical excision

Question 22

what drugs are used in tenosynovial giant cell tumors

Answer 22

M CSF antagonists b/c block proliferation of giant cells

Question 23

what is soft tissue

Answer 23

non epithelial excluding skeleton, joints, CNS, hematopoietic and lymphoid tissues

Question 24

what are more common benign or malignant soft tissue neoplasms

Answer 24

benign all the way

Question 25

most soft tissue tumors arise where

Answer 25

thigh

Question 26

what is big determinant for soft tissue tumor benign vs malignant

Answer 26

above or below fascial plane

Question 27

what translocation for ewing sarcoma

Answer 27

t11;22

Question 28

soft tissue tumor with eosinphilic spindle cells at 90 angles

Answer 28

smooth muscle type

Question 29

soft tissue tumor with short fascicles of spindle cells like spokes on a wheel

Answer 29

fibrohistiocytic

Question 30

soft tissue tumor arranged in columns, palisading

Answer 30

schwann cell

Question 31

what is characteristic of schwannoma

Answer 31

antoni A and B

Question 32

soft tissue tumor with herringbone

Answer 32

fibrosarcoma

Question 33

soft tissue tumor with mixture fascicles of spindle cells and groups epithelioid cells biphasic

Answer 33

synovial sarcoma

Question 34

important prognostic factors in soft tissue tumors

Answer 34

muscle differentiation, degree of differentiation, size and depth

Question 35

what looks like chinese characters on histo

Answer 35

fibrodysplasia

Question 36

what is a benign tumor of fat and most common soft tissue tumor of adulthood

Answer 36

lipoma

Question 37

what are liposarcomas

Answer 37

50s-60s in deep soft tissues in proximal extremities and retroperitoneum

Question 38

subtypes liposarcomas

Answer 38

well differentiated myxoid (basophilic extracellular matrix and capillaries, fetal fat looking like stuff) pleomorphic- sheets anaplastic cells, bizarre nuclei and lots of immature adipocytes

Question 39

what color is the myxoid type liposarcoma

Answer 39

gray

Question 40

what is nodular fascitis

Answer 40

self limited fibroblastic and myofibroblastic proliferation that typically occurs in young adults of upper extremity

Question 41

what is always present in Hx for nodular fascitis

Answer 41

history of trauma

Question 42

5 cm lesion circumscribed, rich cellularity with immature fibroblasts and myofibroblasts in short fascicles cells vary in shape with conspicuous nucleoli lots of mitoses lymphocytes and RBC common

Answer 42

nodular fascitis

Question 43

dupetryns contraction is an example of what

Answer 43

fibromatoses

Question 44

what is pink stuff in fibromatoses

Answer 44

fibrocollagen

Question 45

superficial fibromatosis

Answer 45

infiltrative fibroblastic proliferation | broad fascicles of fibroblasts in long sweeping fascilces with dense collagen

Question 46

what is most comon types of fibromatoses superficial

Answer 46

palmar and plantar

Question 47

what is peyronie disease

Answer 47

penile superficial fibromatoses

Question 48

what are desmoid tumors

Answer 48

deep fibromatosis | recur but no metastasis

Question 49

when do deep fibromatosis present

Answer 49

teens-30s and F>M (weird)

Question 50

types of deep seated fibromatosis

Answer 50

extraabdominal, abdominal and intraabdominal

Question 51

when do you see the extraabdominal deep fibromatosis

Answer 51

W with many babies and C csection scarring

Question 52

gray white firm poorly demarcated mass 1-15 cm rubbery tough with infiltraiton of muscle nerve and fat bland fibroblasts in borad sweeping fascicles

Answer 52

fibromatoses