MSK path VI Flashcards

1
Q

can lead to pyogenic osteomyelitis

A

hematogenous spread
extension from a contiguous site
direct implantation

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2
Q

what microbe is majority of pyogenic osteomyelitis

A

staph aureus

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3
Q

what is microbe that can cause pyogenic osteomyelitis in sickle cell patient

A

salmonella because needs good C’ working to kill it

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4
Q

what is clearing dot on staph aureus culture

A

methicillin

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5
Q

child has subperiosteal abscess, suspect what

A

pyogenic osteomyeltiis

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6
Q

what is sequestrum

A

dead bone

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7
Q

brodie abscess

A

small intraosseous abscess that involves Cx and walled off by reactive bone

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8
Q

what is name of reactive bone that walls of pyogenic osteomyeltiis infection

A

involucrum

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9
Q

osteonecrosis of jaw

A

sclerosing osteomyelitis of Garre

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10
Q

what occurs if see sinus tract in skin oozing thick fluid looks like from bone

A

chronic pyogenic osteomyelitis

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11
Q

malaise fever, chills, leukocytosis, and throbbing pain over bone

A

hematogenous osteomyelitis

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12
Q

Dx osteomyeltisi

A

radiographic finding of lytic lesion surrounded by zone of sclerosis

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13
Q

what is required to identify pathogen in myelitis

A

Bx and bone cultures even if sample blood culture +

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14
Q

Tx osteomyelitis

A

antibiotics and surgical drainage

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15
Q

What is mycobacterial osteomyeltis

A
TB spondylitis (Pott disease)
destructive
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16
Q

benign bone tumors Dx how

A

incidental finding

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17
Q

first hint of bone tumor usually

A

pathologic tumor

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18
Q

needed to definitively Dx bone tumor

A

bone Bx

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19
Q

window where bone tumor likely benign

20
Q

most common primary cancer of bone

A

osteosarcoma

21
Q

what are the malignant bone tumors

A

myeloma and lymphoma

hematopoietic spread

22
Q

what are the benign cartilage forming tumors

A

osteochondroma
chondroma
chondroblastoma
chondromyxoid fibroma

23
Q

what are the malignant cartilage forming tumors

A

chondrosarcoma

24
Q

chondroblastomas involve what part of bone

A

epiphysis of long bones

25
chondromas affect what bones
small bones of hands and eet
26
osteochondroma affect what part of bones
metaphysis long bones
27
myelomas and lymphomas attack what bones
vertebrae and pelvis
28
difference of osteoid osteoma and osteoblastoma
size, sites of origin and Sx
29
what do osteoid osteomas and osteoblastomas look like grossly
round oval masses of gritty hemorrhagic tan tissue
30
rim of osteoid osteomas and osteoblastomas
single layer osteoblasts
31
what encircles osteoid osteoma lesion
lots of reactive bone
32
what is the center of osteoid osteoma called
nidus
33
what do cells of osteosarcoma produce
osteoid matrix or mineralized bone
34
most common primary malignant tumor of bone
osteosarcoma
35
peaks of osteosarcoma
<20 y.o | older adults
36
what is assoc with older age onset osteosarcoma
have pagets or bone infarcts or prior radiation
37
where fo osteosarcoma arise
long bones metaphysis 50% around knee
38
presentation osteosarcoma
painful, progressively enlarging masses | can have sudden fracture
39
radiographs of osteosarcoma
large destructive mixed lytic and blastic mass with infiltrative margins
40
codman triangle
between Cs and periosteum | indicates aggressive tumor
41
distal lytic lesion in bone <20 y.o
osteosarcoma until proven otherwise
42
where o osteosarcomas mets
lungs
43
sites of osteosarcomas
intramedullary, intracortical or surface
44
most common subtype osteosarcoma
primary intramedullary, osteoblastic and high grade
45
color of osteosarcoma
tan white with areas of hemorrhage and cystic degeneration
46
pink stuff in aspirate of osteosarcoma
osteoid
47
prognosis osteosarcoma
if no mets 5 yr 60-70% | if mets <20% 5 yr